1m4v

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[[Image:1m4v.gif|left|200px]]
 
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{{Structure
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==Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus==
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|PDB= 1m4v |SIZE=350|CAPTION= <scene name='initialview01'>1m4v</scene>, resolution 1.90&Aring;
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<StructureSection load='1m4v' size='340' side='right'caption='[[1m4v]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1m4v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4V FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= SET3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [https://pdbe.org/1m4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB], [https://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4v ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4v OCA], [http://www.ebi.ac.uk/pdbsum/1m4v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m4v RCSB]</span>
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[https://www.uniprot.org/uniprot/Q9ZFS6_STAAU Q9ZFS6_STAAU]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4v ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus'''
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==See Also==
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*[[Exotoxin 3D structures|Exotoxin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.
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[[Category: Large Structures]]
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==About this Structure==
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1M4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].
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==Reference==
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The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome., Arcus VL, Langley R, Proft T, Fraser JD, Baker EN, J Biol Chem. 2002 Aug 30;277(35):32274-81. Epub 2002 Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12082105 12082105]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Arcus, V L.]]
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[[Category: Arcus VL]]
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[[Category: Baker, E N.]]
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[[Category: Baker EN]]
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[[Category: Fraser, J D.]]
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[[Category: Fraser JD]]
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[[Category: Langley, R.]]
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[[Category: Langley R]]
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[[Category: Proft, T.]]
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[[Category: Proft T]]
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[[Category: beta-grasp]]
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[[Category: ob-fold]]
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[[Category: superantigen fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:21 2008''
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Current revision

Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus

PDB ID 1m4v

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