3kyr
From Proteopedia
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==Bace-1 in complex with a norstatine type inhibitor== | ==Bace-1 in complex with a norstatine type inhibitor== | ||
| - | <StructureSection load='3kyr' size='340' side='right' caption='[[3kyr]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='3kyr' size='340' side='right'caption='[[3kyr]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3kyr]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3kyr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KYR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=038:3-[[(2S)-2-[[[(2S)-2-[[(2S)-2-[[(2S)-2- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=038:3-[[(2S)-2-[[[(2S)-2-[[(2S)-2-[[(2S)-2-azanyl-3-(1H-1,2,3,4-tetrazol-5-ylcarbonylamino)propanoyl]amino]-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]methyl]-2-hydroxy-4-phenyl-butanoyl]amino]benzoic+acid'>038</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kyr OCA], [https://pdbe.org/3kyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kyr RCSB], [https://www.ebi.ac.uk/pdbsum/3kyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kyr ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> |
==See Also== | ==See Also== | ||
| - | *[[Beta secretase|Beta secretase]] | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Borkakoti | + | [[Category: Borkakoti N]] |
| - | [[Category: Derbyshire | + | [[Category: Derbyshire D]] |
| - | [[Category: Lindberg | + | [[Category: Lindberg JD]] |
| - | [[Category: Nystrom | + | [[Category: Nystrom S]] |
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Current revision
Bace-1 in complex with a norstatine type inhibitor
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