This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2xct

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:24, 9 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==THE TWINNED 3.35A STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH CIPROFLOXACIN AND DNA==
+
==The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA==
-
<StructureSection load='2xct' size='340' side='right' caption='[[2xct]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
+
<StructureSection load='2xct' size='340' side='right'caption='[[2xct]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2xct]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCT FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xcs|2xcs]], [[2xco|2xco]], [[2xcq|2xcq]], [[2xcr|2xcr]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPF:1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>CPF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [https://pdbe.org/2xct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [https://www.ebi.ac.uk/pdbsum/2xct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xct ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xct OCA], [http://pdbe.org/2xct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xct RCSB], [http://www.ebi.ac.uk/pdbsum/2xct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xct ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
+
[https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xct_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xct_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 32: Line 31:
==See Also==
==See Also==
-
*[[Gyrase|Gyrase]]
+
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bax, B D]]
+
[[Category: Large Structures]]
-
[[Category: Brown, K K]]
+
[[Category: Staphylococcus aureus subsp. aureus N315]]
-
[[Category: Chan, P]]
+
[[Category: Synthetic construct]]
-
[[Category: Eggleston, D S]]
+
[[Category: Bax BD]]
-
[[Category: Fosberry, A]]
+
[[Category: Brown KK]]
-
[[Category: Gentry, D R]]
+
[[Category: Chan P]]
-
[[Category: Giordano, I]]
+
[[Category: Eggleston DS]]
-
[[Category: Gorrec, F]]
+
[[Category: Fosberry A]]
-
[[Category: Gwynn, M N]]
+
[[Category: Gentry DR]]
-
[[Category: Hann, M M]]
+
[[Category: Giordano I]]
-
[[Category: Hennessy, A]]
+
[[Category: Gorrec F]]
-
[[Category: Hibbs, M]]
+
[[Category: Gwynn MN]]
-
[[Category: Huang, J]]
+
[[Category: Hann MM]]
-
[[Category: Jones, E]]
+
[[Category: Hennessy A]]
-
[[Category: Jones, J]]
+
[[Category: Hibbs M]]
-
[[Category: Lewis, C J]]
+
[[Category: Huang J]]
-
[[Category: May, E]]
+
[[Category: Jones E]]
-
[[Category: Pearson, N D]]
+
[[Category: Jones J]]
-
[[Category: Shen, C]]
+
[[Category: Lewis CJ]]
-
[[Category: Shillings, A]]
+
[[Category: May E]]
-
[[Category: Singh, O]]
+
[[Category: Pearson ND]]
-
[[Category: Spitzfaden, C]]
+
[[Category: Shen C]]
-
[[Category: Theobald, A]]
+
[[Category: Shillings A]]
-
[[Category: Wohlkonig, A]]
+
[[Category: Singh O]]
-
[[Category: Isomerase-dna-antibiotic complex]]
+
[[Category: Spitzfaden C]]
 +
[[Category: Theobald A]]
 +
[[Category: Wohlkonig A]]

Current revision

The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA

PDB ID 2xct

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xct"
Personal tools