3srh
From Proteopedia
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==Human M2 pyruvate kinase== | ==Human M2 pyruvate kinase== | ||
| - | <StructureSection load='3srh' size='340' side='right' caption='[[3srh]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='3srh' size='340' side='right'caption='[[3srh]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3srh]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3srh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRH FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srh OCA], [https://pdbe.org/3srh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srh RCSB], [https://www.ebi.ac.uk/pdbsum/3srh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srh ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref> |
==See Also== | ==See Also== | ||
| - | *[[Pyruvate | + | *[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Fothergill-Gilmore | + | [[Category: Fothergill-Gilmore LA]] |
| - | [[Category: McNae | + | [[Category: McNae IW]] |
| - | [[Category: Morgan | + | [[Category: Morgan HP]] |
| - | [[Category: Nowicki | + | [[Category: Nowicki MW]] |
| - | [[Category: | + | [[Category: O'Reilly F]] |
| - | [[Category: | + | [[Category: Palmer R]] |
| - | [[Category: Walkinshaw | + | [[Category: Walkinshaw MD]] |
| - | [[Category: Wear | + | [[Category: Wear MA]] |
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Current revision
Human M2 pyruvate kinase
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