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4fz1

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Current revision (20:15, 19 October 2022) (edit) (undo)
 
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==Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH==
==Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH==
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<StructureSection load='4fz1' size='340' side='right' caption='[[4fz1]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
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<StructureSection load='4fz1' size='340' side='right'caption='[[4fz1]], [[Resolution|resolution]] 3.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fz1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FZ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fz1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Psalmopoeus_cambridgei Psalmopoeus cambridgei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fz0|4fz0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz1 OCA], [https://pdbe.org/4fz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fz1 RCSB], [https://www.ebi.ac.uk/pdbsum/4fz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fz1 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASIC1, ACCN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz1 OCA], [http://pdbe.org/4fz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4fz1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fz1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref> [[http://www.uniprot.org/uniprot/TXP1_PSACA TXP1_PSACA]] Potently and selectively blocks the acid-sensing ion channel ASIC1a/ACCN2. The blockade is rapid and reversible. Psalmotoxin 1 loses its capacity to block ASIC1a/ACCN2 as soon as this subunit is associated with another member of the family (ASIC2a/ACCN1 or ASIC3/ACCN3). The toxin can distinguish between the two ASIC1/ACCN2 splice variants ASIC1a/ACCN2 and ASIC1b/ACCN2.<ref>PMID:10829030</ref>
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[https://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chick]]
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[[Category: Gallus gallus]]
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[[Category: Baconguis, I]]
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[[Category: Large Structures]]
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[[Category: Gouaux, E]]
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[[Category: Psalmopoeus cambridgei]]
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[[Category: Inhibitor cystine knot]]
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[[Category: Baconguis I]]
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[[Category: Transport protein]]
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[[Category: Gouaux E]]

Current revision

Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH

PDB ID 4fz1

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