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3wap

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==Crystal structure of Atg13 LIR-fused human LC3C_8-125==
==Crystal structure of Atg13 LIR-fused human LC3C_8-125==
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<StructureSection load='3wap' size='340' side='right' caption='[[3wap]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='3wap' size='340' side='right'caption='[[3wap]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WAP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vtu|3vtu]], [[3vtv|3vtv]], [[3vtw|3vtw]], [[3wal|3wal]], [[3wam|3wam]], [[3wan|3wan]], [[3wao|3wao]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP1LC3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wap OCA], [https://pdbe.org/3wap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wap RCSB], [https://www.ebi.ac.uk/pdbsum/3wap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wap ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wap OCA], [http://pdbe.org/3wap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wap RCSB], [http://www.ebi.ac.uk/pdbsum/3wap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wap ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref>
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[https://www.uniprot.org/uniprot/MLP3C_HUMAN MLP3C_HUMAN] Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.<ref>PMID:23022382</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3wap" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3wap" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dobson, R C.J]]
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[[Category: Large Structures]]
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[[Category: Kato, R]]
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[[Category: Dobson RCJ]]
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[[Category: Kawasaki, M]]
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[[Category: Kato R]]
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[[Category: Morita, E]]
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[[Category: Kawasaki M]]
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[[Category: Suzuki, H]]
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[[Category: Morita E]]
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[[Category: Tabata, K]]
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[[Category: Suzuki H]]
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[[Category: Wakatsuki, S]]
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[[Category: Tabata K]]
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[[Category: Yoshimori, T]]
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[[Category: Wakatsuki S]]
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[[Category: Autophagy]]
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[[Category: Yoshimori T]]
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[[Category: Protein transport]]
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[[Category: Ubiquitin-like fold]]
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Current revision

Crystal structure of Atg13 LIR-fused human LC3C_8-125

PDB ID 3wap

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