4c45

<StructureSection load='4c45' size='340' side='right' caption='[[4c45]], [[Resolution|resolution]] 1.45&Aring;' scene=''>

<table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C45 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4a-hydroxytetrahydrobiopterin_dehydratase 4a-hydroxytetrahydrobiopterin dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.96 4.2.1.96] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [http://pdbe.org/4c45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [http://www.ebi.ac.uk/pdbsum/4c45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c45 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PHS2_HUMAN PHS2_HUMAN]] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

[[Category: 4a-hydroxytetrahydrobiopterin dehydratase]]

[[Category: Human]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Burgess-Brown, N]]

[[Category: Canning, P]]

[[Category: Delft, F von]]

[[Category: Edwards, A]]

[[Category: Kiyani, W]]

[[Category: Kopec, J]]

[[Category: Shrestha, L]]

[[Category: Vollmar, M]]

[[Category: Yue, W W]]

[[Category: Lyase]]