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4czv

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==Structure of the Neurospora crassa Pan2 WD40 domain==
==Structure of the Neurospora crassa Pan2 WD40 domain==
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<StructureSection load='4czv' size='340' side='right' caption='[[4czv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4czv' size='340' side='right'caption='[[4czv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4czv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4czv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4czw|4czw]], [[4czx|4czx]], [[4czy|4czy]], [[4d0k|4d0k]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Poly(A)-specific_ribonuclease Poly(A)-specific ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.13.4 3.1.13.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4czv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czv OCA], [https://pdbe.org/4czv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4czv RCSB], [https://www.ebi.ac.uk/pdbsum/4czv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4czv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4czv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4czv OCA], [http://pdbe.org/4czv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4czv RCSB], [http://www.ebi.ac.uk/pdbsum/4czv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4czv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAN2_NEUCR PAN2_NEUCR]] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pabp-1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails (By similarity).
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[https://www.uniprot.org/uniprot/PAN2_NEUCR PAN2_NEUCR] Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pabp-1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Izaurralde, E]]
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[[Category: Large Structures]]
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[[Category: Jonas, S]]
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[[Category: Neurospora crassa]]
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[[Category: Peter, D]]
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[[Category: Izaurralde E]]
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[[Category: Weichenrieder, O]]
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[[Category: Jonas S]]
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[[Category: Deadenylation]]
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[[Category: Peter D]]
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[[Category: Gene regulation]]
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[[Category: Weichenrieder O]]
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[[Category: Mrna decay]]
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[[Category: Pan2-pan3 complex]]
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[[Category: Scaffold domain]]
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Current revision

Structure of the Neurospora crassa Pan2 WD40 domain

PDB ID 4czv

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