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3t95

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==Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2==
==Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2==
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<StructureSection load='3t95' size='340' side='right' caption='[[3t95]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='3t95' size='340' side='right'caption='[[3t95]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3t95]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis_co92 Yersinia pestis co92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T95 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3t95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T95 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tjy|1tjy]], [[3ejw|3ejw]], [[1tm2|1tm2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lsrB, y3772, YPO0409, YP_3772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214092 Yersinia pestis CO92])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t95 OCA], [https://pdbe.org/3t95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t95 RCSB], [https://www.ebi.ac.uk/pdbsum/3t95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t95 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t95 OCA], [http://pdbe.org/3t95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t95 RCSB], [http://www.ebi.ac.uk/pdbsum/3t95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t95 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LSRB_YERPE LSRB_YERPE]] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
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[https://www.uniprot.org/uniprot/LSRB_YERPE LSRB_YERPE] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P2(1)2(1)2(1), unit-cell parameters a = 40.61, b = 61.03, c = 125.23 A) has been solved by molecular replacement using the structure of LsrB from Salmonella typhimurium (PDB entry 1tjy) and refined to R = 0.180 (R(free) = 0.213) at 1.75 A resolution. The electron density for bound AI-2 and the stereochemistry of the AI-2-binding site are consistent with bound AI-2 adopting the (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran conformation, just as has been observed in the crystal structures of the Salmonella typhimurium and Sinorhizobium meliloti LsrB-AI-2 complexes.
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The structure of LsrB from Yersinia pestis complexed with autoinducer-2.,Kavanaugh JS, Gakhar L, Horswill AR Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1501-5., Epub 2011 Nov 29. PMID:22139152<ref>PMID:22139152</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t95" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Yersinia pestis co92]]
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[[Category: Large Structures]]
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[[Category: Gakhar, L]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Horswill, A R]]
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[[Category: Gakhar L]]
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[[Category: Kavanaugh, J S]]
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[[Category: Horswill AR]]
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[[Category: Periplasmic binding protein fold]]
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[[Category: Kavanaugh JS]]
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[[Category: Periplasmic space]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2

PDB ID 3t95

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