4bwi

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==Structure of the phytochrome Cph2 from Synechocystis sp. PCC6803==
==Structure of the phytochrome Cph2 from Synechocystis sp. PCC6803==
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<StructureSection load='4bwi' size='340' side='right' caption='[[4bwi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4bwi' size='340' side='right'caption='[[4bwi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bwi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cyanobacterium_synechocystis Cyanobacterium synechocystis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BWI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bwi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwi OCA], [http://pdbe.org/4bwi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bwi RCSB], [http://www.ebi.ac.uk/pdbsum/4bwi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwi OCA], [https://pdbe.org/4bwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwi RCSB], [https://www.ebi.ac.uk/pdbsum/4bwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PHY2_SYNY3 PHY2_SYNY3]] Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region.
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[[https://www.uniprot.org/uniprot/PHY2_SYNY3 PHY2_SYNY3]] Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Phytochromes are highly versatile photoreceptors, which occur ubiquitously in plants as well as in many light-responsive microorganisms. Here, photosynthetic cyanobacteria utilize up to three different phytochrome architectures, where only the plant-like and the single-domain cyanobacteriochromes are structurally characterized so far. Cph2 represents a third group in Synechocystis species and affects their capability of phototaxis by controlling c-di-GMP synthesis and degradation. The 2.6 A crystal structure of its red/far-red responsive photosensory module in the Pr state reveals a tandem-GAF bidomain that lacks the figure-of-eight knot of the plant/cph1 subfamily. Its covalently attached phycocyanobilin chromophore adopts a highly tilted ZZZssa conformation with a novel set of interactions between its propionates and the GAF1 domain. The tongue-like protrusion from the GAF2 domain interacts with the GAF1-bound chromophore via its conserved PRxSF, WxE, and WG/AG motifs. Mutagenesis showed that the tongue's integrity is indispensable for Pr--&gt;Pfr photoconversion and involves a swap of the motifs' tryptophans within the tongue-GAF1 interface. This Trp switch is supposed to be a crucial element for the photochromicity of all multi-domain phytochromes.
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Structure of the cyanobacterial phytochrome 2 photosensor implies a tryptophan switch for phytochrome signaling.,Anders K, Daminelli-Widany G, Mroginski MA, von Stetten D, Essen LO J Biol Chem. 2013 Oct 30. PMID:24174528<ref>PMID:24174528</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bwi" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cyanobacterium synechocystis]]
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[[Category: Large Structures]]
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[[Category: Anders, K]]
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[[Category: Synechocystis sp]]
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[[Category: Angerer, V]]
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[[Category: Anders K]]
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[[Category: Essen, L O]]
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[[Category: Angerer V]]
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[[Category: Mroginski, M A]]
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[[Category: Essen L-O]]
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[[Category: Stetten, D v]]
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[[Category: Mroginski MA]]
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[[Category: Widany, G D]]
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[[Category: Widany GD]]
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[[Category: Pcb]]
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[[Category: Von Stetten D]]
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[[Category: Phycocyanobilin]]
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[[Category: Red light photoreceptor]]
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[[Category: Transferase]]
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Current revision

Structure of the phytochrome Cph2 from Synechocystis sp. PCC6803

PDB ID 4bwi

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