This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4esp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:05, 1 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal Structure of Peanut Allergen Ara h 5==
==Crystal Structure of Peanut Allergen Ara h 5==
-
<StructureSection load='4esp' size='340' side='right' caption='[[4esp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
+
<StructureSection load='4esp' size='340' side='right'caption='[[4esp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4esp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arahy Arahy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ESP FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4esp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ESP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ESP FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">profilin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3818 ARAHY])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4esp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esp OCA], [http://pdbe.org/4esp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4esp RCSB], [http://www.ebi.ac.uk/pdbsum/4esp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4esp ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4esp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4esp OCA], [https://pdbe.org/4esp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4esp RCSB], [https://www.ebi.ac.uk/pdbsum/4esp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4esp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/D3K177_ARAHY D3K177_ARAHY]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.[RuleBase:RU003908]
+
[https://www.uniprot.org/uniprot/D3K177_ARAHY D3K177_ARAHY] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.[RuleBase:RU003908]
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Profilins from numerous species are known to be allergens, including food allergens, such as peanut ( Arachis hypogaea ) allergen Ara h 5, and pollen allergens, such as birch allergen Bet v 2. Patients with pollen allergy can also cross-react to peanut. Structural characterization of allergens will allow a better understanding of the allergenicity of food allergens and their cross-reactivities. The three-dimensional structures of most known food allergens remain to be elucidated. Here, we report the first crystallographic study of a food allergen in the profilin family. The structure of peanut allergen Ara h 5 was determined, and the resolution of the final refined structure was 1.1 A. Structure alignment revealed that Ara h 5 is more similar to Bet v 2 than to Hev b 8, although sequence alignment suggested that Ara h 5 is more closely related to Hev b 8 than to Bet v 2, indicating that homology-model-based prediction of immunoglobulin E epitopes needs to be interpreted with caution.
+
-
 
+
-
Crystal Structure of Peanut ( Arachis hypogaea ) Allergen Ara h 5.,Wang Y, Fu TJ, Howard A, Kothary MH, McHugh TH, Zhang Y J Agric Food Chem. 2013 Feb 20;61(7):1573-8. doi: 10.1021/jf303861p. Epub 2013, Feb 11. PMID:23350842<ref>PMID:23350842</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4esp" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
-
*[[Profilin|Profilin]]
+
*[[Profilin 3D Structures|Profilin 3D Structures]]
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Arahy]]
+
[[Category: Arachis hypogaea]]
-
[[Category: Wang, Y]]
+
[[Category: Large Structures]]
-
[[Category: Zhang, Y Z]]
+
[[Category: Wang Y]]
-
[[Category: Allergen]]
+
[[Category: Zhang YZ]]
-
[[Category: Allergy]]
+
-
[[Category: Ara h 5]]
+
-
[[Category: Peanut allergen]]
+
-
[[Category: Profilin]]
+

Current revision

Crystal Structure of Peanut Allergen Ara h 5

PDB ID 4esp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4esp"
Personal tools