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4hib

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==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==
==Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH==
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<StructureSection load='4hib' size='340' side='right' caption='[[4hib]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4hib' size='340' side='right'caption='[[4hib]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HIB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hkp|4hkp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16B:N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>16B</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS, OK/SW-cl.21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [https://pdbe.org/4hib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [https://www.ebi.ac.uk/pdbsum/4hib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hib OCA], [http://pdbe.org/4hib PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hib RCSB], [http://www.ebi.ac.uk/pdbsum/4hib PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hib ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
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[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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*[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]]
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*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Large Structures]]
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[[Category: Kotra, L P]]
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[[Category: Kotra LP]]
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[[Category: Pai, E F]]
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[[Category: Pai EF]]
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[[Category: To, T K]]
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[[Category: To TK]]
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[[Category: Alpa-beta barrel]]
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[[Category: Decarboxylase]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Tim barrel]]
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Current revision

Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N4-OH

PDB ID 4hib

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