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3q0y

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==N-terminal domain of C. reinhardtii SAS-6 homolog Bld12p==
==N-terminal domain of C. reinhardtii SAS-6 homolog Bld12p==
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<StructureSection load='3q0y' size='340' side='right' caption='[[3q0y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3q0y' size='340' side='right'caption='[[3q0y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q0y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlre Chlre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q0y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0Y FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q0x|3q0x]], [[3pyi|3pyi]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CrSAS-6, CrSAS-6 (Bld12p) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3055 CHLRE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0y OCA], [https://pdbe.org/3q0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0y RCSB], [https://www.ebi.ac.uk/pdbsum/3q0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0y OCA], [http://pdbe.org/3q0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q0y RCSB], [http://www.ebi.ac.uk/pdbsum/3q0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0y ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A9CQL4_CHLRE A9CQL4_CHLRE]
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The centriole, and the related basal body, is an ancient organelle characterized by a universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes. The mechanisms directing centriole formation are incompletely understood and represent a fundamental open question in biology. Here, we demonstrate that the centriolar protein SAS-6 forms rod-shaped homodimers that interact through their N-terminal domains to form oligomers. We establish that such oligomerization is essential for centriole formation in C. elegans and human cells. We further generate a structural model of the related protein Bld12p from C. reinhardtii, in which nine homodimers assemble into a ring from which nine coiled-coil rods radiate outward. Moreover, we demonstrate that recombinant Bld12p self-assembles into structures akin to the central hub of the cartwheel, which serves as a scaffold for centriole formation. Overall, our findings establish a structural basis for the universal 9-fold symmetry of centrioles.
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Structural basis of the 9-fold symmetry of centrioles.,Kitagawa D, Vakonakis I, Olieric N, Hilbert M, Keller D, Olieric V, Bortfeld M, Erat MC, Fluckiger I, Gonczy P, Steinmetz MO Cell. 2011 Feb 4;144(3):364-75. PMID:21277013<ref>PMID:21277013</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3q0y" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chlre]]
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[[Category: Chlamydomonas reinhardtii]]
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[[Category: Bortfeld, M]]
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[[Category: Large Structures]]
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[[Category: Erat, M C]]
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[[Category: Bortfeld M]]
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[[Category: Flueckiger, I]]
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[[Category: Erat MC]]
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[[Category: Goenczy, P]]
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[[Category: Flueckiger I]]
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[[Category: Hilbert, M]]
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[[Category: Goenczy P]]
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[[Category: Keller, D]]
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[[Category: Hilbert M]]
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[[Category: Kitagawa, D]]
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[[Category: Keller D]]
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[[Category: Olieric, N]]
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[[Category: Kitagawa D]]
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[[Category: Olieric, V]]
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[[Category: Olieric N]]
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[[Category: Steinmetz, M O]]
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[[Category: Olieric V]]
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[[Category: Vakonakis, I]]
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[[Category: Steinmetz MO]]
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[[Category: Centrosome protein]]
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[[Category: Vakonakis I]]
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[[Category: Structural protein]]
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Current revision

N-terminal domain of C. reinhardtii SAS-6 homolog Bld12p

PDB ID 3q0y

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