1mh1

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[[Image:1mh1.jpg|left|200px]]
 
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{{Structure
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==SMALL G-PROTEIN==
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|PDB= 1mh1 |SIZE=350|CAPTION= <scene name='initialview01'>1mh1</scene>, resolution 1.38&Aring;
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<StructureSection load='1mh1' size='340' side='right'caption='[[1mh1]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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<table><tr><td colspan='2'>[[1mh1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MH1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
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|GENE= RHO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mh1 OCA], [https://pdbe.org/1mh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mh1 RCSB], [https://www.ebi.ac.uk/pdbsum/1mh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mh1 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mh1 OCA], [http://www.ebi.ac.uk/pdbsum/1mh1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mh1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RAC1_HUMAN RAC1_HUMAN] Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref> Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.<ref>PMID:1643658</ref> <ref>PMID:9121475</ref> <ref>PMID:19934221</ref> <ref>PMID:19403692</ref> <ref>PMID:20696765</ref>
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== Evolutionary Conservation ==
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'''SMALL G-PROTEIN'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/1mh1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mh1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.
The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.
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==Disease==
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The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.,Hirshberg M, Stockley RW, Dodson G, Webb MR Nat Struct Biol. 1997 Feb;4(2):147-52. PMID:9033596<ref>PMID:9033596</ref>
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Known disease associated with this structure: Night blindness, congenital stationery, rhodopsin-related OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180380 180380]], Retinitis pigmentosa, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180380 180380]], Retinitis pigmentosa-4, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=180380 180380]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1MH1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MH1 OCA].
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</div>
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<div class="pdbe-citations 1mh1" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue., Hirshberg M, Stockley RW, Dodson G, Webb MR, Nat Struct Biol. 1997 Feb;4(2):147-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9033596 9033596]
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*[[Rac 3D structures|Rac 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dodson, G.]]
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[[Category: Dodson G]]
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[[Category: Hirshberg, M.]]
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[[Category: Hirshberg M]]
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[[Category: Stockley, R W.]]
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[[Category: Stockley RW]]
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[[Category: Webb, M R.]]
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[[Category: Webb MR]]
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[[Category: gtp-binding]]
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[[Category: gtpase]]
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[[Category: ras super family]]
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[[Category: rho family]]
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[[Category: small g-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:56 2008''
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Current revision

SMALL G-PROTEIN

PDB ID 1mh1

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