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3j5y

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==Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP==
==Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP==
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<StructureSection load='3j5y' size='340' side='right' caption='[[3j5y]], [[Resolution|resolution]] 9.70&Aring;' scene=''>
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<SX load='3j5y' size='340' side='right' viewer='molstar' caption='[[3j5y]], [[Resolution|resolution]] 9.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j5y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j2k 3j2k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J5Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j5y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j2k 3j2k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J5Y FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETF1, ERF1, RF1, SUP45L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GSPT1, ERF3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j5y OCA], [http://pdbe.org/3j5y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j5y RCSB], [http://www.ebi.ac.uk/pdbsum/3j5y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j5y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j5y OCA], [https://pdbe.org/3j5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j5y RCSB], [https://www.ebi.ac.uk/pdbsum/3j5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j5y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/ERF3A_HUMAN ERF3A_HUMAN]] Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
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[https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[TRNA|TRNA]]
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*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Frank, J]]
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[[Category: Frank J]]
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[[Category: Georges, A des]]
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[[Category: Grassucci RA]]
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[[Category: Grassucci, R A]]
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[[Category: Hashem Y]]
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[[Category: Hashem, Y]]
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[[Category: Hellen CUT]]
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[[Category: Hellen, C U.T]]
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[[Category: Pestova TV]]
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[[Category: Pestova, T V]]
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[[Category: Taylor D]]
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[[Category: Taylor, D]]
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[[Category: Unbehaun A]]
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[[Category: Unbehaun, A]]
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[[Category: Des Georges A]]
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[[Category: Erf1]]
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[[Category: Erf3]]
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[[Category: Mammalian]]
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[[Category: Ribosome]]
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[[Category: Translation termination]]
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[[Category: Translation-rna complex]]
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[[Category: Trnaleu]]
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Current revision

Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP

3j5y, resolution 9.70Å

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