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3ur4
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==Crystal structure of human WD repeat domain 5 with compound== | ==Crystal structure of human WD repeat domain 5 with compound== | ||
| - | <StructureSection load='3ur4' size='340' side='right' caption='[[3ur4]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3ur4' size='340' side='right'caption='[[3ur4]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ur4]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ur4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UR4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0BW:METHYL+3-[(3-METHOXYBENZOYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE'>0BW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BW:METHYL+3-[(3-METHOXYBENZOYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE'>0BW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ur4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ur4 OCA], [https://pdbe.org/3ur4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ur4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ur4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ur4 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> |
==See Also== | ==See Also== | ||
| - | *[[WD-repeat protein | + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Al-Awar | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Al-Awar R]] |
| - | [[Category: Bolshan | + | [[Category: Allali Hassani A]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Brown | + | [[Category: Bolshan Y]] |
| - | [[Category: Chau | + | [[Category: Bountra C]] |
| - | [[Category: Dombrovski | + | [[Category: Brown P]] |
| - | [[Category: Dong | + | [[Category: Chau I]] |
| - | [[Category: Edwards | + | [[Category: Dombrovski L]] |
| - | [[Category: Hajian | + | [[Category: Dong A]] |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Nguyen | + | [[Category: Hajian T]] |
| - | [[Category: Poda | + | [[Category: Nguyen KT]] |
| - | + | [[Category: Poda G]] | |
| - | [[Category: Schapira | + | [[Category: Schapira M]] |
| - | [[Category: Senisterra | + | [[Category: Senisterra G]] |
| - | [[Category: Smil | + | [[Category: Smil D]] |
| - | [[Category: Vedadi | + | [[Category: Vedadi M]] |
| - | [[Category: Wasney | + | [[Category: Wasney GA]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Wernimont | + | [[Category: Wernimont A]] |
| - | [[Category: Wu | + | [[Category: Wu H]] |
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Current revision
Crystal structure of human WD repeat domain 5 with compound
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Categories: Homo sapiens | Large Structures | Al-Awar R | Allali Hassani A | Arrowsmith CH | Bolshan Y | Bountra C | Brown P | Chau I | Dombrovski L | Dong A | Edwards AM | Hajian T | Nguyen KT | Poda G | Schapira M | Senisterra G | Smil D | Vedadi M | Wasney GA | Weigelt J | Wernimont A | Wu H
