3v1w
From Proteopedia
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| ==Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin== | ==Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin== | ||
| - | <StructureSection load='3v1w' size='340' side='right' caption='[[3v1w]], [[Resolution|resolution]] 1.91Å' scene=''> | + | <StructureSection load='3v1w' size='340' side='right'caption='[[3v1w]], [[Resolution|resolution]] 1.91Å' scene=''> | 
| == Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3v1w]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3v1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V1W FirstGlance]. <br> | 
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.908Å</td></tr> | 
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | 
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v1w OCA], [https://pdbe.org/3v1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v1w RCSB], [https://www.ebi.ac.uk/pdbsum/3v1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v1w ProSAT]</span></td></tr> | ||
| </table> | </table> | ||
| == Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CASQ1_RABIT CASQ1_RABIT] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). | 
| __TOC__ | __TOC__ | ||
| </StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| [[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
| - | [[Category: Kang | + | [[Category: Kang C]] | 
| - | [[Category: Lewis | + | [[Category: Lewis KM]] | 
| - | [[Category: Muralidharan | + | [[Category: Muralidharan AK]] | 
| - | [[Category: Nissen | + | [[Category: Nissen MN]] | 
| - | [[Category: Sanchez | + | [[Category: Sanchez EJ]] | 
| - | [[Category: Subramanian | + | [[Category: Subramanian AK]] | 
| - | + | ||
| - | + | ||
Current revision
Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin
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