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4ae5

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STRUCTURE OF A MAJOR REGULATOR OF STAPHYLOCOCCAL PATHOGENESIS

Structural highlights

4ae5 is a 4 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.85Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRAP_STAA8 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Up-regulates the expression of most toxins and genes known to be necessary for biofilm formation.^[1] ^[2]

Publication Abstract from PubMed

The crystal structure of the signal transduction protein TRAP is reported at 1.85 A resolution. The structure of TRAP consists of a central eight-stranded beta-barrel flanked asymmetrically by helices and is monomeric both in solution and in the crystal structure. A formate ion was found bound to TRAP identically in all four molecules in the asymmetric unit.

Structure of the signal transduction protein TRAP (target of RNAIII-activating protein).,Henrick K, Hirshberg M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):744-50., Epub 2012 Jun 22. PMID:22750855^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Balaban N, Goldkorn T, Gov Y, Hirshberg M, Koyfman N, Matthews HR, Nhan RT, Singh B, Uziel O. Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating Protein (TRAP). J Biol Chem. 2001 Jan 26;276(4):2658-67. PMID:11160124 doi:10.1074/jbc.m005446200
↑ Korem M, Gov Y, Kiran MD, Balaban N. Transcriptional profiling of target of RNAIII-activating protein, a master regulator of staphylococcal virulence. Infect Immun. 2005 Oct;73(10):6220-8. PMID:16177293 doi:10.1128/IAI.73.10.6220-6228.2005
↑ Henrick K, Hirshberg M. Structure of the signal transduction protein TRAP (target of RNAIII-activating protein). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):744-50., Epub 2012 Jun 22. PMID:22750855 doi:10.1107/S1744309112020167

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ae5"

Categories: Large Structures | Staphylococcus aureus | Henrick K | Hirshberg M

@@ Line 1: / Line 1: @@
 ==STRUCTURE OF A MAJOR REGULATOR OF STAPHYLOCOCCAL PATHOGENESIS==
-<StructureSection load='4ae5' size='340' side='right' caption='[[4ae5]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+<StructureSection load='4ae5' size='340' side='right'caption='[[4ae5]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ae5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AE5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ae5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AE5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ae5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae5 OCA], [http://pdbe.org/4ae5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ae5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ae5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae5 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae5 OCA], [https://pdbe.org/4ae5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TRAP_STAAN TRAP_STAAN]] Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation (By similarity).
+[https://www.uniprot.org/uniprot/TRAP_STAA8 TRAP_STAA8] Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Up-regulates the expression of most toxins and genes known to be necessary for biofilm formation.<ref>PMID:11160124</ref> <ref>PMID:16177293</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 23: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Staphylococcus aureus]]
-[[Category: Henrick, K]]
+[[Category: Henrick K]]
-[[Category: Hirshberg, M]]
+[[Category: Hirshberg M]]
-[[Category: Biofilm]]
-[[Category: Phosphorylation]]
-[[Category: Quorum sensing]]
-[[Category: Rap]]
-[[Category: Rnaiii]]
-[[Category: Signaling protein]]
-[[Category: Toxin production]]

4ae5

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Current revision

STRUCTURE OF A MAJOR REGULATOR OF STAPHYLOCOCCAL PATHOGENESIS

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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