4hnx

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==The NatA Acetyltransferase Complex Bound To ppGpp==
==The NatA Acetyltransferase Complex Bound To ppGpp==
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<StructureSection load='4hnx' size='340' side='right' caption='[[4hnx]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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<StructureSection load='4hnx' size='340' side='right'caption='[[4hnx]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hnx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HNX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hnx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HNX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.339&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hnw|4hnw]], [[4hny|4hny]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAT1, AAA1, YDL040C, D2720 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), ARD1, YHR013C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnx OCA], [https://pdbe.org/4hnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hnx RCSB], [https://www.ebi.ac.uk/pdbsum/4hnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hnx ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_alpha-N-acetyltransferase Peptide alpha-N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.88 2.3.1.88] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hnx OCA], [http://pdbe.org/4hnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hnx RCSB], [http://www.ebi.ac.uk/pdbsum/4hnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hnx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NAT1_YEAST NAT1_YEAST]] Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.<ref>PMID:1600941</ref> <ref>PMID:14517307</ref> [[http://www.uniprot.org/uniprot/ARD1_YEAST ARD1_YEAST]] Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.<ref>PMID:1600941</ref>
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[https://www.uniprot.org/uniprot/NAT1_YEAST NAT1_YEAST] Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.<ref>PMID:1600941</ref> <ref>PMID:14517307</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: Peptide alpha-N-acetyltransferase]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Dollins, D E]]
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[[Category: Dollins DE]]
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[[Category: Endo-Streeter, S T]]
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[[Category: Endo-Streeter ST]]
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[[Category: IV, C W.Pemble]]
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[[Category: Immormino RM]]
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[[Category: Immormino, R M]]
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[[Category: Neubauer JL]]
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[[Category: Neubauer, J L]]
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[[Category: Pemble IV CW]]
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[[Category: York, J D]]
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[[Category: York JD]]
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[[Category: Gnat/tpr]]
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[[Category: N-terminal acetyltransferase]]
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[[Category: Ppgpp]]
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[[Category: Transferase]]
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Current revision

The NatA Acetyltransferase Complex Bound To ppGpp

PDB ID 4hnx

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