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| | ==Crystal structure analysis of Class-I MHC restricted T-cell associated molecule== | | ==Crystal structure analysis of Class-I MHC restricted T-cell associated molecule== |
| - | <StructureSection load='3rbg' size='340' side='right' caption='[[3rbg]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3rbg' size='340' side='right'caption='[[3rbg]], [[Resolution|resolution]] 2.30Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3rbg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RBG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3rbg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBG FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRTAM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbg OCA], [http://pdbe.org/3rbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rbg RCSB], [http://www.ebi.ac.uk/pdbsum/3rbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbg ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbg OCA], [https://pdbe.org/3rbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbg RCSB], [https://www.ebi.ac.uk/pdbsum/3rbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbg ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN]] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7] | + | [https://www.uniprot.org/uniprot/CRTAM_HUMAN CRTAM_HUMAN] Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.<ref>PMID:15811952</ref> [UniProtKB:Q149L7] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Almo, S C]] | + | [[Category: Large Structures]] |
| - | [[Category: Fiser, A]] | + | [[Category: Almo SC]] |
| - | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network]] | + | [[Category: Fiser A]] |
| - | [[Category: Structural genomic]]
| + | [[Category: Nathenson SG]] |
| - | [[Category: Nathenson, S G]] | + | [[Category: Ramagopal UA]] |
| - | [[Category: Ramagopal, U A]] | + | [[Category: Rubinstein R]] |
| - | [[Category: Rubinstein, R]] | + | [[Category: Toro R]] |
| - | [[Category: Toro, R]] | + | |
| - | [[Category: Atoms-to-animals: the immune function network]]
| + | |
| - | [[Category: Crtam]]
| + | |
| - | [[Category: Ifn]]
| + | |
| - | [[Category: Igv]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Nysgrc]]
| + | |
| - | [[Category: Psi-biology]]
| + | |
| Structural highlights
Function
CRTAM_HUMAN Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.[1] [UniProtKB:Q149L7]
Publication Abstract from PubMed
The members of the immunoglobulin superfamily (IgSF) control innate and adaptive immunity and are prime targets for the treatment of autoimmune diseases, infectious diseases, and malignancies. We describe a computational method, termed the Brotherhood algorithm, which utilizes intermediate sequence information to classify proteins into functionally related families. This approach identifies functional relationships within the IgSF and predicts additional receptor-ligand interactions. As a specific example, we examine the nectin/nectin-like family of cell adhesion and signaling proteins and propose receptor-ligand interactions within this family. Guided by the Brotherhood approach, we present the high-resolution structural characterization of a homophilic interaction involving the class-I MHC-restricted T-cell-associated molecule, which we now classify as a nectin-like family member. The Brotherhood algorithm is likely to have a significant impact on structural immunology by identifying those proteins and complexes for which structural characterization will be particularly informative.
Functional classification of immune regulatory proteins.,Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005 Aug 1;106(3):779-86. Epub 2005 Apr 5. PMID:15811952 doi:10.1182/blood-2005-02-0817
- ↑ Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A. Functional classification of immune regulatory proteins. Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr, 11. PMID:23583034 doi:10.1016/j.str.2013.02.022
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