3onr

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==Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site==
==Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site==
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<StructureSection load='3onr' size='340' side='right' caption='[[3onr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3onr' size='340' side='right'caption='[[3onr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3onr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ONR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3onr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ONR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0379, secE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3onr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3onr OCA], [http://pdbe.org/3onr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3onr RCSB], [http://www.ebi.ac.uk/pdbsum/3onr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3onr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3onr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3onr OCA], [https://pdbe.org/3onr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3onr RCSB], [https://www.ebi.ac.uk/pdbsum/3onr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3onr ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/DODEC_MYCTU DODEC_MYCTU] Binds calcium ions. May play a role in sequestering additional small ligands.<ref>PMID:21370306</ref>
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In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis identify the orthologs of Ca dodecins with different ligand-binding specificity.
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Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.,Arockiasamy A, Aggarwal A, Savva CG, Holzenburg A, Sacchettini JC Protein Sci. 2011 Mar 2. doi: 10.1002/pro.607. PMID:21370306<ref>PMID:21370306</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3onr" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arulandu, A]]
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[[Category: Large Structures]]
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[[Category: Sacchettini, J C]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Calcium binding protein]]
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[[Category: Arulandu A]]
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[[Category: Calcium dodecin]]
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[[Category: Sacchettini JC]]
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[[Category: Dodecamer]]
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[[Category: Imuuno dominant antigen]]
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[[Category: Metal binding protein]]
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Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site

PDB ID 3onr

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