4o6i

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==2.0A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain==
==2.0A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain==
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<StructureSection load='4o6i' size='340' side='right' caption='[[4o6i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4o6i' size='340' side='right'caption='[[4o6i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_Armstrong) Lymphocytic choriomeningitis virus (strain Armstrong)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o6h|4o6h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6i OCA], [http://pdbe.org/4o6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6i RCSB], [http://www.ebi.ac.uk/pdbsum/4o6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6i OCA], [https://pdbe.org/4o6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6i RCSB], [https://www.ebi.ac.uk/pdbsum/4o6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCAP_LYCVA NCAP_LYCVA]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation.<ref>PMID:12610166</ref> <ref>PMID:17804508</ref> <ref>PMID:22532683</ref>
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[https://www.uniprot.org/uniprot/NCAP_LYCVA NCAP_LYCVA] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation.<ref>PMID:12610166</ref> <ref>PMID:17804508</ref> <ref>PMID:22532683</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4o6i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4o6i" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hastie, K M]]
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[[Category: Large Structures]]
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[[Category: Saphire, E O]]
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[[Category: Hastie KM]]
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[[Category: West, B R]]
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[[Category: Saphire EO]]
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[[Category: Exoribonuclease]]
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[[Category: West BR]]
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[[Category: Hydrolase]]
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[[Category: Ribonucleoprotein]]
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Current revision

2.0A crystal structure of Lymphocytic Choriomeningitis Virus Nucleoprotein C-terminal Domain

PDB ID 4o6i

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