4bwx

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==Structure of Neurospora crassa PAN3 pseudokinase mutant==
==Structure of Neurospora crassa PAN3 pseudokinase mutant==
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<StructureSection load='4bwx' size='340' side='right' caption='[[4bwx]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='4bwx' size='340' side='right'caption='[[4bwx]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BWX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bwk|4bwk]], [[4bwp|4bwp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwx OCA], [http://pdbe.org/4bwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bwx RCSB], [http://www.ebi.ac.uk/pdbsum/4bwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwx OCA], [https://pdbe.org/4bwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwx RCSB], [https://www.ebi.ac.uk/pdbsum/4bwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAN3_NEUCR PAN3_NEUCR]] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab-1. Deadenylation of the 3'-tail to a length that is too short to bind pab-1 induces mRNA decay. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan-3 acts as a positive regulator for PAN activity, recruiting pan-2 to mRNA via its interaction with pab-1 (By similarity).
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[https://www.uniprot.org/uniprot/PAN3_NEUCR PAN3_NEUCR] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab-1. Deadenylation of the 3'-tail to a length that is too short to bind pab-1 induces mRNA decay. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan-3 acts as a positive regulator for PAN activity, recruiting pan-2 to mRNA via its interaction with pab-1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ribonuclease|Ribonuclease]]
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chrysonilia crassa]]
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[[Category: Large Structures]]
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[[Category: Boland, A]]
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[[Category: Neurospora crassa]]
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[[Category: Christie, M]]
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[[Category: Boland A]]
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[[Category: Huntzinger, E]]
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[[Category: Christie M]]
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[[Category: Izaurralde, E]]
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[[Category: Huntzinger E]]
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[[Category: Weichenrieder, O]]
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[[Category: Izaurralde E]]
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[[Category: Deadenylase]]
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[[Category: Weichenrieder O]]
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[[Category: Gene regulation]]
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[[Category: Mirna]]
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[[Category: Mrna decay]]
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[[Category: Pan2]]
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Current revision

Structure of Neurospora crassa PAN3 pseudokinase mutant

PDB ID 4bwx

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