1mqt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:47, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mqt.gif|left|200px]]
 
-
{{Structure
+
==Swine Vesicular Disease Virus coat protein==
-
|PDB= 1mqt |SIZE=350|CAPTION= <scene name='initialview01'>1mqt</scene>, resolution 3.30&Aring;
+
<StructureSection load='1mqt' size='340' side='right'caption='[[1mqt]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene>
+
<table><tr><td colspan='2'>[[1mqt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Swine_vesicular_disease_virus Swine vesicular disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQT FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPL:OCTANOIC+ACID+(2-HYDROXY-1-HYDROXYMETHYL-HEPTADEC-3-ENYL)-AMIDE'>SPL</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqt OCA], [https://pdbe.org/1mqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqt RCSB], [https://www.ebi.ac.uk/pdbsum/1mqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqt ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1cov|1COV]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqt OCA], [http://www.ebi.ac.uk/pdbsum/1mqt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mqt RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/Q8B8X4_9ENTO Q8B8X4_9ENTO]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqt_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqt ConSurf].
 +
<div style="clear:both"></div>
-
'''Swine Vesicular Disease Virus coat protein'''
+
==See Also==
-
 
+
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The structure of swine vesicular disease virus (SVDV) was solved and refined at a 3.0-A resolution by X-ray crystallography to gain information about the role of sequence changes that occurred as this virus evolved from the parental human pathogen coxsackievirus B5 (CVB5). These amino acid substitutions can be clustered in five distinct regions: (i) the antigenic sites, (ii) the hydrophobic pocket of the VP1 beta-sandwich, (iii) the putative CAR binding site, (iv) the putative heparan sulfate binding site, and (v) the fivefold axis. The VP1 pocket is occupied by a branched pocket factor, apparently different from that present in the closely related virus CVB3 and in other picornaviruses. This finding may be relevant for the design of new antiviral compounds against this site. Density consistent with the presence of ions was observed on the fivefold and threefold axes. The structure also provided an accurate description of the putative receptor binding sites.
+
[[Category: Large Structures]]
-
 
+
-
==About this Structure==
+
-
1MQT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Swine_vesicular_disease_virus Swine vesicular disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQT OCA].
+
-
 
+
-
==Reference==
+
-
Structure of swine vesicular disease virus: mapping of changes occurring during adaptation of human coxsackie B5 virus to infect swine., Verdaguer N, Jimenez-Clavero MA, Fita I, Ley V, J Virol. 2003 Sep;77(18):9780-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12941886 12941886]
+
-
[[Category: Protein complex]]
+
[[Category: Swine vesicular disease virus]]
[[Category: Swine vesicular disease virus]]
-
[[Category: Fita, I.]]
+
[[Category: Fita I]]
-
[[Category: Jimenez-Clavero, M A.]]
+
[[Category: Jimenez-Clavero MA]]
-
[[Category: Ley, V.]]
+
[[Category: Ley V]]
-
[[Category: Verdaguer, N.]]
+
[[Category: Verdaguer N]]
-
[[Category: enterovirus]]
+
-
[[Category: icosahedral virus]]
+
-
[[Category: svdv coat protein]]
+
-
[[Category: swine vesicular disease virus]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:50 2008''
+

Current revision

Swine Vesicular Disease Virus coat protein

PDB ID 1mqt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mqt"
Personal tools