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| | ==Crystal structure of rhesus macaque MHC class I molecule Mamu-B*17-IW9== | | ==Crystal structure of rhesus macaque MHC class I molecule Mamu-B*17-IW9== |
| - | <StructureSection load='3rwc' size='340' side='right' caption='[[3rwc]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='3rwc' size='340' side='right'caption='[[3rwc]], [[Resolution|resolution]] 2.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3rwc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RWC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3rwc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RWC FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rwd|3rwd]], [[3rwe|3rwe]], [[3rwf|3rwf]], [[3rwg|3rwg]], [[3rwh|3rwh]], [[3rwi|3rwi]], [[3rwj|3rwj]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MHCI-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwc OCA], [https://pdbe.org/3rwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rwc RCSB], [https://www.ebi.ac.uk/pdbsum/3rwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwc ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rwc OCA], [http://pdbe.org/3rwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rwc RCSB], [http://www.ebi.ac.uk/pdbsum/3rwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rwc ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU]] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] [[http://www.uniprot.org/uniprot/B2MG_MACMU B2MG_MACMU]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | + | [https://www.uniprot.org/uniprot/Q9GJ77_MACMU Q9GJ77_MACMU] Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| - | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| - | *[[Major histocompatibility complex|Major histocompatibility complex]] | + | *[[MHC 3D structures|MHC 3D structures]] |
| | + | *[[MHC I 3D structures|MHC I 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Macmu]] | + | [[Category: Large Structures]] |
| - | [[Category: Gao, F]] | + | [[Category: Macaca mulatta]] |
| - | [[Category: Gao, G F]] | + | [[Category: Simian immunodeficiency virus]] |
| - | [[Category: Liu, J]] | + | [[Category: Gao F]] |
| - | [[Category: Price, D A]] | + | [[Category: Gao GF]] |
| - | [[Category: Qi, J X]] | + | [[Category: Liu J]] |
| - | [[Category: Wu, Y]] | + | [[Category: Price DA]] |
| - | [[Category: Antigenic peptide]] | + | [[Category: Qi JX]] |
| - | [[Category: Immune response]] | + | [[Category: Wu Y]] |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: T lymphocyte]]
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| Structural highlights
Function
Q9GJ77_MACMU Involved in the presentation of foreign antigens to the immune system (By similarity).[SAAS:SAAS003006_004_004364]
Publication Abstract from PubMed
The MHC class I molecule Mamu-B*17 has been associated with elite control of SIV infection in rhesus macaques, akin to the protective effects described for HLA-B*57 in HIV-infected individuals. In this study, we determined the crystal structures of Mamu-B*17 in complex with eight different peptides corresponding to immunodominant SIV(mac)239-derived CD8(+) T cell epitopes: HW8 (HLEVQGYW), GW10 (GSHLEVQGYW), MW9 (MHPAQTSQW), QW9 (QTSQWDDPW), FW9 (FQWMGYELW), MF8 (MRHVLEPF), IW9 (IRYPKTFGW), and IW11 (IRYPKTFGWLW). The structures reveal that not only P2, but also P1 and P3, can be used as N-terminal anchor residues by Mamu-B*17-restricted peptides. Moreover, the N-terminal anchor residues exhibit a broad chemical specificity, encompassing basic (H and R), bulky polar aliphatic (Q), and small (T) residues. In contrast, Mamu-B*17 exhibits a very narrow preference for aromatic residues (W and F) at the C terminus, similar to that displayed by HLA-B*57. Flexibility within the whole peptide-binding groove contributes to the accommodation of these diverse peptides, which adopt distinct conformations. Furthermore, the unusually large pocket D enables compensation from other peptide residues if P3 is occupied by an amino acid with a small side chain. In addition, residues located at likely TCR contact regions present highly flexible conformations, which may impact TCR repertoire profiles. These findings provide novel insights into the structural basis of diverse peptide accommodation by Mamu-B*17 and highlight unique atomic features that might contribute to the protective effect of this MHC I molecule in SIV-infected rhesus macaques.
Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus.,Wu Y, Gao F, Liu J, Qi J, Gostick E, Price DA, Gao GF J Immunol. 2011 Dec 15;187(12):6382-92. Epub 2011 Nov 14. PMID:22084443[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Wu Y, Gao F, Liu J, Qi J, Gostick E, Price DA, Gao GF. Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus. J Immunol. 2011 Dec 15;187(12):6382-92. Epub 2011 Nov 14. PMID:22084443 doi:10.4049/jimmunol.1101726
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