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3wgt

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==Crystal structure of D-amino acid oxidase mutant==
==Crystal structure of D-amino acid oxidase mutant==
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<StructureSection load='3wgt' size='340' side='right' caption='[[3wgt]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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<StructureSection load='3wgt' size='340' side='right'caption='[[3wgt]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wgt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WGT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wgt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WGT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=QSC:(1R)-1-PHENYLETHANAMINE'>QSC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DAO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=QSC:(1R)-1-PHENYLETHANAMINE'>QSC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wgt OCA], [https://pdbe.org/3wgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wgt RCSB], [https://www.ebi.ac.uk/pdbsum/3wgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wgt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wgt OCA], [http://pdbe.org/3wgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wgt RCSB], [http://www.ebi.ac.uk/pdbsum/3wgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wgt ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
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[https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Amino acid oxidase|Amino acid oxidase]]
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: D-amino-acid oxidase]]
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[[Category: Large Structures]]
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[[Category: Pig]]
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[[Category: Sus scrofa]]
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[[Category: Asano, Y]]
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[[Category: Asano Y]]
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[[Category: Nakano, S]]
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[[Category: Nakano S]]
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[[Category: Yasukawa, K]]
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[[Category: Yasukawa K]]
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[[Category: Fad-binding]]
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[[Category: Oxidase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of D-amino acid oxidase mutant

PDB ID 3wgt

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