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3p65

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Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme

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 ==Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme==
-<StructureSection load='3p65' size='340' side='right' caption='[[3p65]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='3p65' size='340' side='right'caption='[[3p65]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3p65]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P65 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3p65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P65 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=AU3:GOLD+3++ION'>AU3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p4z|3p4z]], [[3p64|3p64]], [[3p66|3p66]], [[3p68|3p68]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=AU3:GOLD+3++ION'>AU3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p65 OCA], [https://pdbe.org/3p65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p65 RCSB], [https://www.ebi.ac.uk/pdbsum/3p65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p65 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p65 OCA], [http://pdbe.org/3p65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p65 RCSB], [http://www.ebi.ac.uk/pdbsum/3p65 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p65 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
+[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Gold nanoparticles are useful in biomedical applications due to their distinct optical properties and high chemical stability. Reports of the biogenic formation of gold colloids from gold complexes has also led to an increased level of interest in the biomineralization of gold. However, the mechanism responsible for biomolecule-directed gold nanoparticle formation remains unclear due to the lack of structural information about biological systems and the fast kinetics of biomimetic chemical systems in solution. Here we show that intact single crystals of lysozyme can be used to study the time-dependent, protein-directed growth of gold nanoparticles. The protein crystals slow down the growth of the gold nanoparticles, allowing detailed kinetic studies to be carried out, and permit a three-dimensional structural characterization that would be difficult to achieve in solution. Furthermore, we show that additional chemical species can be used to fine-tune the growth rate of the gold nanoparticles.
-Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.,Wei H, Wang Z, Zhang J, House S, Gao YG, Yang L, Robinson H, Tan LH, Xing H, Hou C, Robertson IM, Zuo JM, Lu Y Nat Nanotechnol. 2011 Feb;6(2):93-7. Epub 2011 Jan 30. PMID:21278750<ref>PMID:21278750</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 3p65" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 27: / Line 17: @@
 __TOC__
 </StructureSection>
-[[Category: Chick]]
+[[Category: Gallus gallus]]
-[[Category: Lysozyme]]
+[[Category: Large Structures]]
-[[Category: Gao, Y G]]
+[[Category: Gao Y-G]]
-[[Category: Hou, C]]
+[[Category: Hou C]]
-[[Category: House, S]]
+[[Category: House S]]
-[[Category: Lu, Y]]
+[[Category: Lu Y]]
-[[Category: Robertson, I M]]
+[[Category: Robertson IM]]
-[[Category: Robinson, H]]
+[[Category: Robinson H]]
-[[Category: Tan, L H]]
+[[Category: Tan LH]]
-[[Category: Wang, Z]]
+[[Category: Wang Z]]
-[[Category: Wei, H]]
+[[Category: Wei H]]
-[[Category: Xing, H]]
+[[Category: Xing H]]
-[[Category: Yang, L]]
+[[Category: Yang L]]
-[[Category: Zhang, J]]
+[[Category: Zhang J]]
-[[Category: Zuo, J M]]
+[[Category: Zuo J-M]]
-[[Category: Binding site]]
-[[Category: Bio-nano hybrid]]
-[[Category: Gold nanoparticle]]
-[[Category: Hydrolase]]
-[[Category: Porous material]]

3p65

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Time-dependent and Protein-directed In Situ Growth of Gold Nanoparticles in a Single Crystal of Lysozyme

Structural highlights

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