3lfk

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==A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators==
==A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators==
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<StructureSection load='3lfk' size='340' side='right' caption='[[3lfk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='3lfk' size='340' side='right'caption='[[3lfk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lfk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thevo Thevo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LFK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lfk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_volcanium_GSS1 Thermoplasma volcanium GSS1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LFK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TV0762, TVG0766549 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273116 THEVO])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lfk OCA], [http://pdbe.org/3lfk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lfk RCSB], [http://www.ebi.ac.uk/pdbsum/3lfk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lfk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lfk OCA], [https://pdbe.org/3lfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lfk RCSB], [https://www.ebi.ac.uk/pdbsum/3lfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lfk ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q97AP8_THEVO Q97AP8_THEVO]
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Several archaeal mechanosensitive (MS) channels have been reported, including one from Thermoplasma volcanium designated MscTV. Here, we report the crystal structure of MscTV at 1.6-A resolution. Unexpectedly, MscTV was found to be a water-soluble protein exhibiting a winged helix-turn-helix (wHTH) motif, which is the signature of the MarR (multiple antibiotic resistance regulator) family of transcriptional regulators. A cell-based osmotic downshock functional assay demonstrated that MscTV was unable to protect a knockout strain of Escherichia coli from hypoosmotic shock, further indicating that it does not function as a MS channel. We propose this protein be renamed MLPTv for MarR-like protein from T. volcanium.
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A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators.,Liu Z, Walton TA, Rees DC Protein Sci. 2010 Apr;19(4):808-14. PMID:20162616<ref>PMID:20162616</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3lfk" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thevo]]
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[[Category: Large Structures]]
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[[Category: Liu, Z]]
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[[Category: Thermoplasma volcanium GSS1]]
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[[Category: Rees, D C]]
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[[Category: Liu Z]]
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[[Category: Walton, T A]]
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[[Category: Rees DC]]
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[[Category: Mechanosensitive channel]]
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[[Category: Walton TA]]
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[[Category: Multiple antibiotic resistance regulator]]
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[[Category: Transcriptional regulator]]
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[[Category: Unknown function]]
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[[Category: Winged helix-turn-helix motif]]
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Current revision

A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators

PDB ID 3lfk

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