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4m63

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==Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL==
==Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL==
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<StructureSection load='4m63' size='340' side='right' caption='[[4m63]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='4m63' size='340' side='right'caption='[[4m63]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m63]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome] and [http://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_bb22op Vibrio parahaemolyticus bb22op]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M63 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m63]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_BB22OP Vibrio parahaemolyticus BB22OP]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M63 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.748&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VopL, VPBB_A1249 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1211705 Vibrio parahaemolyticus BB22OP]), 5C-actin, Act5C, CG4027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m63 OCA], [https://pdbe.org/4m63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m63 RCSB], [https://www.ebi.ac.uk/pdbsum/4m63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m63 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m63 OCA], [http://pdbe.org/4m63 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m63 RCSB], [http://www.ebi.ac.uk/pdbsum/4m63 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m63 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACT1_DROME ACT1_DROME]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
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[https://www.uniprot.org/uniprot/ACT1_DROME ACT1_DROME] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosinetriphosphatase]]
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[[Category: Drosophila melanogaster]]
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[[Category: Drome]]
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[[Category: Large Structures]]
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[[Category: Vibrio parahaemolyticus bb22op]]
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[[Category: Vibrio parahaemolyticus BB22OP]]
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[[Category: Rosen, M K]]
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[[Category: Rosen MK]]
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[[Category: Tomchick, D R]]
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[[Category: Tomchick DR]]
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[[Category: Zahm, J A]]
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[[Category: Zahm JA]]
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[[Category: Actin nucleation]]
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[[Category: Actin nucleator]]
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[[Category: Actin-binding protein]]
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[[Category: Atp-binding protein]]
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[[Category: Cytoskeleton]]
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[[Category: Hydrolase]]
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[[Category: Vopl c-terminal domain]]
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[[Category: Wasp homology 2 domain]]
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Current revision

Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL

PDB ID 4m63

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