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4hxq

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==Crystal structure of human Arginase-1 complexed with inhibitor 14==
==Crystal structure of human Arginase-1 complexed with inhibitor 14==
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<StructureSection load='4hxq' size='340' side='right' caption='[[4hxq]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='4hxq' size='340' side='right'caption='[[4hxq]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hxq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HXQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HXQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X8A:[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X8A</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d3v|1d3v]], [[2aeb|2aeb]], [[4hww|4hww]], [[4hze|4hze]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X8A:[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X8A</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hxq OCA], [https://pdbe.org/4hxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hxq RCSB], [https://www.ebi.ac.uk/pdbsum/4hxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hxq ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hxq OCA], [http://pdbe.org/4hxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hxq RCSB], [http://www.ebi.ac.uk/pdbsum/4hxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hxq ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
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[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Arginase|Arginase]]
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*[[Arginase 3D structures|Arginase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Andreoli, M]]
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[[Category: Andreoli M]]
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[[Category: Beckett , P]]
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[[Category: Beckett P]]
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[[Category: Conway, B]]
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[[Category: Conway B]]
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[[Category: Cousido-Siah, A]]
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[[Category: Cousido-Siah A]]
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[[Category: Golebiowski, A]]
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[[Category: Golebiowski A]]
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[[Category: Ji, M]]
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[[Category: Ji M]]
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[[Category: Mahboubi, K]]
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[[Category: Mahboubi K]]
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[[Category: Mitschler, A]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A]]
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[[Category: Podjarny A]]
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[[Category: Ruiz, F X]]
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[[Category: Ruiz FX]]
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[[Category: Schroeter, H]]
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[[Category: Schroeter H]]
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[[Category: Sheeler, R]]
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[[Category: Sheeler R]]
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[[Category: Whitehouse, D L]]
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[[Category: Van Zandt MC]]
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[[Category: Zandt, M C.Van]]
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[[Category: Whitehouse DL]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Alpha/beta fold]]
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[[Category: Arginine metabolism]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Manganese]]
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[[Category: Metalloenzyme]]
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Current revision

Crystal structure of human Arginase-1 complexed with inhibitor 14

PDB ID 4hxq

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