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4uuj

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==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==
==POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM==
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<StructureSection load='4uuj' size='340' side='right' caption='[[4uuj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4uuj' size='340' side='right'caption='[[4uuj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uuj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UUJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [http://pdbe.org/4uuj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [http://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=IND:INDOLE'>IND</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=XA7:TETRAHEXYL+AMMONNIUM'>XA7</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuj OCA], [https://pdbe.org/4uuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uuj RCSB], [https://www.ebi.ac.uk/pdbsum/4uuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uuj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4uuj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4uuj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Burdette, D]]
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[[Category: Large Structures]]
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[[Category: Focia, P J]]
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[[Category: Mus musculus]]
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[[Category: Gross, A]]
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[[Category: Streptomyces lividans]]
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[[Category: Lenaeus, M J]]
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[[Category: Burdette D]]
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[[Category: Wagner, T]]
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[[Category: Focia PJ]]
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[[Category: Immune system-metal transport complex]]
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[[Category: Gross A]]
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[[Category: Ion transport]]
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[[Category: Lenaeus MJ]]
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[[Category: Ionic channel]]
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[[Category: Wagner T]]
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[[Category: Potassium channel]]
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[[Category: Protein-antibody fab complex]]
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[[Category: Quaternary ammonium]]
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Current revision

POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM

PDB ID 4uuj

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