4me3

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==1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM==
==1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM==
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<StructureSection load='4me3' size='340' side='right' caption='[[4me3]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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<StructureSection load='4me3' size='340' side='right'caption='[[4me3]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4me3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ME3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4me3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ME3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.794&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ta0799 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 "Thermoplasma acidophila" (sic) Darland et al. 1970])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me3 OCA], [http://pdbe.org/4me3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4me3 RCSB], [http://www.ebi.ac.uk/pdbsum/4me3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4me3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me3 OCA], [https://pdbe.org/4me3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4me3 RCSB], [https://www.ebi.ac.uk/pdbsum/4me3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4me3 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9HK10_THEAC Q9HK10_THEAC]
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Mini-chromosome maintenance (MCM) proteins are the replicative helicase necessary for DNA replication in both eukarya and archaea. Most of archaea only have one MCM gene. Here, we report a 1.8-A crystal structure of the N-terminal MCM from the archaeon Thermoplasma acidophilum (tapMCM). In the structure, the MCM N-terminus forms a right-handed filament that contains six subunits in each turn, with a diameter of 25A of the central channel opening. The inner surface is highly positively charged, indicating DNA binding. This filament structure with six subunits per turn may also suggests a potential role for an open-ring structure for hexameric MCM and dynamic conformational changes in initiation and elongation stages of DNA replication.
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The 1.8-A Crystal Structure of the N-Terminal Domain of an Archaeal MCM as a Right-Handed Filament.,Fu Y, Slaymaker IM, Wang J, Wang G, Chen XS J Mol Biol. 2013 Dec 27. pii: S0022-2836(13)00812-7. doi:, 10.1016/j.jmb.2013.12.025. PMID:24378617<ref>PMID:24378617</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4me3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, X S]]
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[[Category: Large Structures]]
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[[Category: Fu, Y]]
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[[Category: Thermoplasma acidophilum]]
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[[Category: Slaymaker, I M]]
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[[Category: Chen XS]]
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[[Category: Wang, G]]
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[[Category: Fu Y]]
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[[Category: Aaa+]]
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[[Category: Slaymaker IM]]
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[[Category: Helicase]]
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[[Category: Wang G]]
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[[Category: Replication]]
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[[Category: Zinc binding domain]]
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Current revision

1.8 Angstrom Crystal Structure of the N-terminal Domain of an Archaeal MCM

PDB ID 4me3

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