2x4y

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==MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BY THE PWWP DOMAIN OF BRPF1.==
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==Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.==
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<StructureSection load='2x4y' size='340' side='right' caption='[[2x4y]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='2x4y' size='340' side='right'caption='[[2x4y]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x4y]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x4y]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x35|2x35]], [[2d9e|2d9e]], [[2x4x|2x4x]], [[2x4w|2x4w]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4y OCA], [https://pdbe.org/2x4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4y RCSB], [https://www.ebi.ac.uk/pdbsum/2x4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4y OCA], [http://pdbe.org/2x4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4y RCSB], [http://www.ebi.ac.uk/pdbsum/2x4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4y ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4y_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 2x4y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2x4y" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peregrin|Peregrin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Allen, M D]]
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[[Category: Large Structures]]
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[[Category: Bonadies, N]]
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[[Category: Allen MD]]
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[[Category: Bycroft, M]]
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[[Category: Bonadies N]]
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[[Category: Freund, S M.V]]
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[[Category: Bycroft M]]
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[[Category: Gottgens, B]]
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[[Category: Freund SMV]]
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[[Category: Huntly, B J.P]]
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[[Category: Gottgens B]]
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[[Category: Kvinlaug, B]]
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[[Category: Huntly BJP]]
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[[Category: Santiveri, C M]]
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[[Category: Kvinlaug B]]
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[[Category: Vezzoli, A]]
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[[Category: Santiveri CM]]
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[[Category: Chromatin regulator]]
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[[Category: Vezzoli A]]
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[[Category: Metal-binding]]
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[[Category: Nucleosome]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.

PDB ID 2x4y

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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