4qmg

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==The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions==
==The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions==
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<StructureSection load='4qmg' size='340' side='right' caption='[[4qmg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4qmg' size='340' side='right'caption='[[4qmg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qmg]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QMG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qmg]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QMG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3omc|3omc]], [[2e6n|2e6n]], [[3omg|3omg]], [[3bdl|3bdl]], [[2hqe|2hqe]], [[2hqx|2hqx]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qmg OCA], [https://pdbe.org/4qmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qmg RCSB], [https://www.ebi.ac.uk/pdbsum/4qmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qmg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qmg OCA], [http://pdbe.org/4qmg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qmg RCSB], [http://www.ebi.ac.uk/pdbsum/4qmg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qmg ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/SND1_HUMAN SND1_HUMAN]] Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).<ref>PMID:7651391</ref> [[http://www.uniprot.org/uniprot/LYRIC_HUMAN LYRIC_HUMAN]] Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.<ref>PMID:15927426</ref> <ref>PMID:16452207</ref> <ref>PMID:18316612</ref> <ref>PMID:19111877</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guo, F]]
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[[Category: Homo sapiens]]
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[[Category: Kang, Y]]
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[[Category: Large Structures]]
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[[Category: Satyshur, K]]
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[[Category: Guo F]]
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[[Category: Stanevich, V]]
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[[Category: Kang Y]]
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[[Category: Wan, L]]
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[[Category: Satyshur K]]
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[[Category: Xing, Y]]
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[[Category: Stanevich V]]
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[[Category: Breast cancer]]
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[[Category: Wan L]]
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[[Category: Dna/rna-binding]]
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[[Category: Xing Y]]
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[[Category: Mirna-mediated silencing]]
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[[Category: Mtdh]]
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[[Category: Nuclease]]
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[[Category: Sn domain]]
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[[Category: Snd1]]
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[[Category: Transcription]]
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[[Category: Tumorigenesis]]
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The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions

PDB ID 4qmg

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