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4wp0

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==Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag==
==Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag==
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<StructureSection load='4wp0' size='340' side='right' caption='[[4wp0]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4wp0' size='340' side='right'caption='[[4wp0]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wp0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WP0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wp0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WP0 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IT1:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>IT1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wlh|4wlh]], [[4wlj|4wlj]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wp0 OCA], [http://pdbe.org/4wp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wp0 RCSB], [http://www.ebi.ac.uk/pdbsum/4wp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wp0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wp0 OCA], [https://pdbe.org/4wp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wp0 RCSB], [https://www.ebi.ac.uk/pdbsum/4wp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wp0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>
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[https://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref>
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==See Also==
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Akladios, F N]]
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[[Category: Homo sapiens]]
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[[Category: Church, W B]]
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[[Category: Large Structures]]
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[[Category: Collyer, C A]]
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[[Category: Akladios FN]]
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[[Category: Gorrell, M D]]
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[[Category: Church WB]]
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[[Category: Kapoor, V]]
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[[Category: Collyer CA]]
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[[Category: Nadvi, N A]]
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[[Category: Gorrell MD]]
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[[Category: Park, J]]
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[[Category: Kapoor V]]
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[[Category: Salam, N K]]
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[[Category: Nadvi NA]]
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[[Category: Plp dependent pyridoxal phosphate transaminase aminotransferase cofactor lysine modification alpha beta protein]]
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[[Category: Park J]]
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[[Category: Salam NK]]

Current revision

Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag

PDB ID 4wp0

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