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| | ==VP17, a capsid protein of bacteriophage P23-77== | | ==VP17, a capsid protein of bacteriophage P23-77== |
| - | <StructureSection load='3zmn' size='340' side='right' caption='[[3zmn]], [[Resolution|resolution]] 2.26Å' scene=''> | + | <StructureSection load='3zmn' size='340' side='right'caption='[[3zmn]], [[Resolution|resolution]] 2.26Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3zmn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_phage_p23-77 Thermus phage p23-77]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZMN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3zmn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_virus_P23-77 Thermus virus P23-77]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZMN FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zmo|3zmo]], [[3zn4|3zn4]], [[3zn5|3zn5]], [[3zn6|3zn6]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zmn OCA], [https://pdbe.org/3zmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zmn RCSB], [https://www.ebi.ac.uk/pdbsum/3zmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zmn ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zmn OCA], [http://pdbe.org/3zmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zmn RCSB], [http://www.ebi.ac.uk/pdbsum/3zmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zmn ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/C8CHL5_9VIRU C8CHL5_9VIRU] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Thermus phage p23-77]] | + | [[Category: Large Structures]] |
| - | [[Category: Bamford, J K.H]] | + | [[Category: Thermus virus P23-77]] |
| - | [[Category: Grimes, J M]] | + | [[Category: Bamford JKH]] |
| - | [[Category: Harlos, K]] | + | [[Category: Grimes JM]] |
| - | [[Category: Mantynen, S]] | + | [[Category: Harlos K]] |
| - | [[Category: Pawlowski, A]] | + | [[Category: Mantynen S]] |
| - | [[Category: Rissanen, I]] | + | [[Category: Pawlowski A]] |
| - | [[Category: Stuart, D I]] | + | [[Category: Rissanen I]] |
| - | [[Category: Viral protein]]
| + | [[Category: Stuart DI]] |
| Structural highlights
Function
C8CHL5_9VIRU
Publication Abstract from PubMed
It has proved difficult to classify viruses unless they are closely related since their rapid evolution hinders detection of remote evolutionary relationships in their genetic sequences. However, structure varies more slowly than sequence, allowing deeper evolutionary relationships to be detected. Bacteriophage P23-77 is an example of a newly identified viral lineage, with members inhabiting extreme environments. We have solved multiple crystal structures of the major capsid proteins VP16 and VP17 of bacteriophage P23-77. They fit the 14 A resolution cryo-electron microscopy reconstruction of the entire virus exquisitely well, allowing us to propose a model for both the capsid architecture and viral assembly, quite different from previously published models. The structures of the capsid proteins and their mode of association to form the viral capsid suggest that the P23-77-like and adeno-PRD1 lineages of viruses share an extremely ancient common ancestor.
Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.,Rissanen I, Grimes JM, Pawlowski A, Mantynen S, Harlos K, Bamford JK, Stuart DI Structure. 2013 May 7;21(5):718-26. doi: 10.1016/j.str.2013.02.026. Epub 2013 Apr, 25. PMID:23623731[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Rissanen I, Grimes JM, Pawlowski A, Mantynen S, Harlos K, Bamford JK, Stuart DI. Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage. Structure. 2013 May 7;21(5):718-26. doi: 10.1016/j.str.2013.02.026. Epub 2013 Apr, 25. PMID:23623731 doi:10.1016/j.str.2013.02.026
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