3vqg

<StructureSection load='3vqg' size='340' side='right' caption='[[3vqg]], [[Resolution|resolution]] 1.35&Aring;' scene=''>

<table><tr><td colspan='2'>[[3vqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VQG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vqf|3vqf]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Lnx1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqg OCA], [http://pdbe.org/3vqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vqg RCSB], [http://www.ebi.ac.uk/pdbsum/3vqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqg ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. [[http://www.uniprot.org/uniprot/IGSF5_MOUSE IGSF5_MOUSE]] Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells.<ref>PMID:12773569</ref> <ref>PMID:16982697</ref>

*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]

[[Category: Lk3 transgenic mice]]

[[Category: Akiyoshi, Y]]

[[Category: Furuse, M]]

[[Category: Goda, N]]

[[Category: Hamada, D]]

[[Category: Hiroaki, H]]

[[Category: Nakagawa, A]]

[[Category: Narita, H]]

[[Category: Suzuki, M]]

[[Category: Tenno, T]]

[[Category: Peptide binding protein]]