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2vc5

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==STRUCTURAL BASIS FOR NATURAL LACTONASE AND PROMISCUOUS PHOSPHOTRIESTERASE ACTIVITIES==
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==Structural basis for natural lactonase and promiscuous phosphotriesterase activities==
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<StructureSection load='2vc5' size='340' side='right' caption='[[2vc5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='2vc5' size='340' side='right'caption='[[2vc5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vc5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vc5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VC5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vc7|2vc7]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc5 OCA], [https://pdbe.org/2vc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc5 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc5 OCA], [http://pdbe.org/2vc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PHP_SULSO PHP_SULSO]] Has a low paraoxonase activity. Also active, but with a lower activity, against other oregano-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>
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[https://www.uniprot.org/uniprot/PHP_SACS2 PHP_SACS2] Has a low paraoxonase activity. Also active, but with a lower activity, against other organo-phosphorus insecticides such as Dursban, Coumaphos, pNP-butanoate or parathion.<ref>PMID:15909078</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vc5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vc5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Phosphotriesterase|Phosphotriesterase]]
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*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
*[[Serum Paraoxonase|Serum Paraoxonase]]
*[[Serum Paraoxonase|Serum Paraoxonase]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aryldialkylphosphatase]]
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[[Category: Large Structures]]
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[[Category: Atcc 35091]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Chabriere, E]]
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[[Category: Chabriere E]]
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[[Category: Dupuy, J]]
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[[Category: Dupuy J]]
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[[Category: Elias, M]]
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[[Category: Elias M]]
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[[Category: Lecomte, C]]
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[[Category: Lecomte C]]
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[[Category: Manco, G]]
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[[Category: Manco G]]
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[[Category: Mandrich, L]]
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[[Category: Mandrich L]]
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[[Category: Masson, P]]
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[[Category: Masson P]]
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[[Category: Merone, L]]
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[[Category: Merone L]]
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[[Category: Moniot, S]]
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[[Category: Moniot S]]
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[[Category: Rossi, M]]
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[[Category: Rossi M]]
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[[Category: Biotechnology]]
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[[Category: Enzyme evolution]]
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[[Category: Hydrolase]]
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[[Category: Hyperthermophilic]]
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[[Category: Lactonase]]
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[[Category: Phosphotriesterase]]
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[[Category: Promiscuous activity]]
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[[Category: Quorum sensing]]
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Current revision

Structural basis for natural lactonase and promiscuous phosphotriesterase activities

PDB ID 2vc5

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