1mzb

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[[Image:1mzb.jpg|left|200px]]
 
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{{Structure
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==Ferric uptake regulator==
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|PDB= 1mzb |SIZE=350|CAPTION= <scene name='initialview01'>1mzb</scene>, resolution 1.8&Aring;
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<StructureSection load='1mzb' size='340' side='right'caption='[[1mzb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1mzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MZB FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzb OCA], [https://pdbe.org/1mzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mzb RCSB], [https://www.ebi.ac.uk/pdbsum/1mzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mzb ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzb OCA], [http://www.ebi.ac.uk/pdbsum/1mzb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mzb RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/FUR_PSEAE FUR_PSEAE] Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility.
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== Evolutionary Conservation ==
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'''Ferric uptake regulator'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/1mzb_consurf.spt"</scriptWhenChecked>
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Iron is an essential element for almost all organisms, although an overload of this element results in toxicity because of the formation of hydroxyl radicals. Consequently, most living entities have developed sophisticated mechanisms to control their intracellular iron concentration. In many bacteria, including the opportunistic pathogen Pseudomonas aeruginosa, this task is performed by the ferric uptake regulator (Fur). Fur controls a wide variety of basic physiological processes including iron uptake systems and the expression of exotoxin A. Here, we present the first crystal structure of Fur from P. aeruginosa in complex with Zn2+ determined at a resolution of 1.8 A. Furthermore, X-ray absorption spectroscopic measurements and microPIXE analysis were performed in order to characterize the distinct zinc and iron binding sites in solution. The combination of these complementary techniques enables us to present a model for the activation and DNA binding of the Fur protein.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1MZB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZB OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mzb ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator., Pohl E, Haller JC, Mijovilovich A, Meyer-Klaucke W, Garman E, Vasil ML, Mol Microbiol. 2003 Feb;47(4):903-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12581348 12581348]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Haller JC]]
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[[Category: Haller, J C.]]
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[[Category: Pohl E]]
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[[Category: Pohl, E.]]
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[[Category: Vasil ML]]
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[[Category: Vasil, M L.]]
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[[Category: dtxr]]
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[[Category: ferric uptake regulator]]
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[[Category: iron]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:13 2008''
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Current revision

Ferric uptake regulator

PDB ID 1mzb

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