4ac3

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==S.pneumoniae GlmU in complex with an antibacterial inhibitor==
==S.pneumoniae GlmU in complex with an antibacterial inhibitor==
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<StructureSection load='4ac3' size='340' side='right' caption='[[4ac3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4ac3' size='340' side='right'caption='[[4ac3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ac3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ac3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R83:N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)SULFAMOYL]PHENYL}ACETAMIDE'>R83</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4aaw|4aaw]], [[4aa7|4aa7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R83:N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)SULFAMOYL]PHENYL}ACETAMIDE'>R83</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ac3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ac3 OCA], [http://pdbe.org/4ac3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ac3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ac3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ac3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ac3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ac3 OCA], [https://pdbe.org/4ac3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ac3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ac3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ac3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLMU_STRR6 GLMU_STRR6]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity).
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[https://www.uniprot.org/uniprot/GLMU_STRR6 GLMU_STRR6] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ac3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ac3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[N-acetylglucosamine-1-phosphate uridyltransferase|N-acetylglucosamine-1-phosphate uridyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Breed, J]]
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[[Category: Large Structures]]
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[[Category: Ogg, D J]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Otterbein, L]]
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[[Category: Breed J]]
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[[Category: Acetyl transferase]]
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[[Category: Ogg DJ]]
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[[Category: Transferase]]
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[[Category: Otterbein L]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

S.pneumoniae GlmU in complex with an antibacterial inhibitor

PDB ID 4ac3

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