4qin

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==Structure of the human smoothened receptor in complex with SAG1.5==
==Structure of the human smoothened receptor in complex with SAG1.5==
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<StructureSection load='4qin' size='340' side='right' caption='[[4qin]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4qin' size='340' side='right'caption='[[4qin]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qin]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QIN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qin]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QIN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SG8:3-CHLORO-4,7-DIFLUORO-N-[TRANS-4-(METHYLAMINO)CYCLOHEXYL]-N-[3-(PYRIDIN-4-YL)BENZYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE'>SG8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o9r|4o9r]], [[4qim|4qim]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SG8:3-CHLORO-4,7-DIFLUORO-N-[TRANS-4-(METHYLAMINO)CYCLOHEXYL]-N-[3-(PYRIDIN-4-YL)BENZYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE'>SG8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qin OCA], [http://pdbe.org/4qin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qin RCSB], [http://www.ebi.ac.uk/pdbsum/4qin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qin ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qin OCA], [https://pdbe.org/4qin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qin RCSB], [https://www.ebi.ac.uk/pdbsum/4qin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qin ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caron, M G]]
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[[Category: Escherichia coli]]
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[[Category: Cherezov, V]]
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[[Category: Homo sapiens]]
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[[Category: Evron, T]]
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[[Category: Large Structures]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Caron MG]]
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[[Category: Han, G W]]
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[[Category: Cherezov V]]
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[[Category: Huang, X P]]
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[[Category: Evron T]]
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[[Category: Hufeisen, S J]]
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[[Category: Han GW]]
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[[Category: Katritch, V]]
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[[Category: Huang X-P]]
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[[Category: Mangano, T J]]
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[[Category: Hufeisen SJ]]
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[[Category: Roth, B L]]
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[[Category: Katritch V]]
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[[Category: Stevens, R C]]
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[[Category: Mangano TJ]]
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[[Category: Urban, D J]]
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[[Category: Roth BL]]
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[[Category: Vardy, E]]
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[[Category: Stevens RC]]
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[[Category: Wang, C]]
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[[Category: Urban DJ]]
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[[Category: Wu, H]]
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[[Category: Vardy E]]
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[[Category: Agonist]]
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[[Category: Wang C]]
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[[Category: Gpcr]]
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[[Category: Wu H]]
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[[Category: Gpcr network]]
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[[Category: Human smoothened receptor]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Structure of the human smoothened receptor in complex with SAG1.5

PDB ID 4qin

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