3eyi

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==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==
==The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA==
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<StructureSection load='3eyi' size='340' side='right' caption='[[3eyi]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='3eyi' size='340' side='right'caption='[[3eyi]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EYI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3eyi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EYI FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C20orf183, DLM1, ZBP1, ZBP1/DLM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [http://pdbe.org/3eyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [http://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyi OCA], [https://pdbe.org/3eyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eyi RCSB], [https://www.ebi.ac.uk/pdbsum/3eyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eyi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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[https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/3eyi_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/3eyi_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3eyi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3eyi" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Z-DNA|Z-DNA]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ha, S C]]
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[[Category: Large Structures]]
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[[Category: Kim, K K]]
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[[Category: Ha SC]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Kim KK]]
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[[Category: Dna binding protein-z-dna complex]]
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[[Category: Dna-binding]]
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Current revision

The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA

PDB ID 3eyi

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