1n38

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[[Image:1n38.gif|left|200px]]
 
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{{Structure
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==reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed==
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|PDB= 1n38 |SIZE=350|CAPTION= <scene name='initialview01'>1n38</scene>, resolution 2.8&Aring;
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<StructureSection load='1n38' size='340' side='right'caption='[[1n38]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CH1:3&#39;-DEOXY-CYTIDINE-5&#39;-TRIPHOSPHATE'>CH1</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=U3H:3&#39;-DEOXY-URIDINE+5&#39;-TRIPHOSPHATE'>U3H</scene>
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<table><tr><td colspan='2'>[[1n38]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N38 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian orthoreovirus 3])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CH1:3-DEOXY-CYTIDINE-5-TRIPHOSPHATE'>CH1</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=U3H:3-DEOXY-URIDINE+5-TRIPHOSPHATE'>U3H</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n38 OCA], [https://pdbe.org/1n38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n38 RCSB], [https://www.ebi.ac.uk/pdbsum/1n38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n38 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1muk|1MUK]], [[1mwh|1MWH]], [[1n1h|1N1H]], [[1n35|1N35]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n38 OCA], [http://www.ebi.ac.uk/pdbsum/1n38 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n38 RCSB]</span>
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== Function ==
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[https://www.uniprot.org/uniprot/RDRP_REOVD RDRP_REOVD] RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.
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'''reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
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[[Category: Large Structures]]
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[[Category: Mammalian orthoreovirus 3 Dearing]]
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==About this Structure==
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[[Category: Farsetta DL]]
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1N38 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3 Mammalian orthoreovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N38 OCA].
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[[Category: Harrison SC]]
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[[Category: Nibert ML]]
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==Reference==
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[[Category: Tao Y]]
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RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12464184 12464184]
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[[Category: Mammalian orthoreovirus 3]]
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[[Category: Single protein]]
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[[Category: Farsetta, D L.]]
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[[Category: Harrison, S C.]]
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[[Category: Nibert, M L.]]
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[[Category: Tao, Y.]]
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[[Category: bracelet]]
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[[Category: right hand configuration]]
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[[Category: rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:46 2008''
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Current revision

reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed

PDB ID 1n38

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