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4gv2

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==Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354==
==Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354==
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<StructureSection load='4gv2' size='340' side='right' caption='[[4gv2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4gv2' size='340' side='right'caption='[[4gv2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gv2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GV2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GV2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5ME:3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[(1R)-1-(PYRIDIN-2-YL)ETHYL]PROPANAMIDE'>5ME</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gv0|4gv0]], [[4gv4|4gv4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ME:3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[(1R)-1-(PYRIDIN-2-YL)ETHYL]PROPANAMIDE'>5ME</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv2 OCA], [https://pdbe.org/4gv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gv2 RCSB], [https://www.ebi.ac.uk/pdbsum/4gv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv2 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv2 OCA], [http://pdbe.org/4gv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gv2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
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[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Andersson, C D]]
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[[Category: Large Structures]]
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[[Category: Ekblad, T]]
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[[Category: Andersson CD]]
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[[Category: Elofsson, M]]
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[[Category: Ekblad T]]
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[[Category: Karlberg, T]]
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[[Category: Elofsson M]]
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[[Category: Lindgren, A E.G]]
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[[Category: Karlberg T]]
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[[Category: Linusson, A]]
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[[Category: Lindgren AEG]]
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[[Category: Schuler, H]]
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[[Category: Linusson A]]
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[[Category: Spjut, S]]
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[[Category: Schuler H]]
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[[Category: Thorsell, A G]]
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[[Category: Spjut S]]
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[[Category: Weigelt, J]]
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[[Category: Thorsell AG]]
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[[Category: Adp- ribosylation]]
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[[Category: Weigelt J]]
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[[Category: Adp-ribose]]
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[[Category: Adp-ribosylation]]
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[[Category: Artd transferase domain]]
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[[Category: Artd3]]
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[[Category: Nad]]
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[[Category: Parp3]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354

PDB ID 4gv2

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