1n66

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[[Image:1n66.gif|left|200px]]
 
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{{Structure
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==Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR==
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|PDB= 1n66 |SIZE=350|CAPTION= <scene name='initialview01'>1n66</scene>
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<StructureSection load='1n66' size='340' side='right'caption='[[1n66]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1n66]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N66 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n66 OCA], [https://pdbe.org/1n66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n66 RCSB], [https://www.ebi.ac.uk/pdbsum/1n66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n66 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[255d|255D]], [[1zif|1ZIF]]
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n66 OCA], [http://www.ebi.ac.uk/pdbsum/1n66 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n66 RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR'''
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==Overview==
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Formation of non-canonical base-pairs in RNA often plays a very important functional role. In addition they frequently serve as factors in stabilizing the secondary structure elements that provide the frame of large compact RNA structures. Here we describe the structure of an internal loop containing a 5'CU3'/5'UU3' non-canonical tandem base-pair motif, which is conserved within the 3'-UTR of poliovirus-like enteroviruses. Structural details reveal striking regularities of the local helix geometry, resulting from alternating geometrical adjustments, which are important for understanding and predicting stabilities and configurations of tandem non-canonical base-pairs. The C-U and U-U base-pairs severely contract the minor groove of the sugar-phosphate backbone, which might be important for protein recognition or binding to other RNA elements.
Formation of non-canonical base-pairs in RNA often plays a very important functional role. In addition they frequently serve as factors in stabilizing the secondary structure elements that provide the frame of large compact RNA structures. Here we describe the structure of an internal loop containing a 5'CU3'/5'UU3' non-canonical tandem base-pair motif, which is conserved within the 3'-UTR of poliovirus-like enteroviruses. Structural details reveal striking regularities of the local helix geometry, resulting from alternating geometrical adjustments, which are important for understanding and predicting stabilities and configurations of tandem non-canonical base-pairs. The C-U and U-U base-pairs severely contract the minor groove of the sugar-phosphate backbone, which might be important for protein recognition or binding to other RNA elements.
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==About this Structure==
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Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs.,Lescrinier EM, Tessari M, van Kuppeveld FJ, Melchers WJ, Hilbers CW, Heus HA J Mol Biol. 2003 Aug 22;331(4):759-69. PMID:12909008<ref>PMID:12909008</ref>
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1N66 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N66 OCA].
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==Reference==
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Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs., Lescrinier EM, Tessari M, van Kuppeveld FJ, Melchers WJ, Hilbers CW, Heus HA, J Mol Biol. 2003 Aug 22;331(4):759-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12909008 12909008]
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[[Category: Protein complex]]
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[[Category: Heus, H A.]]
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[[Category: Hilbers, C W.]]
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[[Category: Kuppeveld, F J.van.]]
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[[Category: Lescrinier, E M.]]
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[[Category: Melchers, W J.]]
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[[Category: Tessari, M.]]
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[[Category: rna internal loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:25:57 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1n66" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Heus HA]]
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[[Category: Hilbers CW]]
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[[Category: Lescrinier EM]]
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[[Category: Melchers WJ]]
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[[Category: Tessari M]]
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[[Category: Van Kuppeveld FJ]]

Current revision

Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR

PDB ID 1n66

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