2n26

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==Solution structure of Miz-1 zinc fingers 3 and 4==
==Solution structure of Miz-1 zinc fingers 3 and 4==
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<StructureSection load='2n26' size='340' side='right' caption='[[2n26]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n26' size='340' side='right'caption='[[2n26]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n26]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N26 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N26 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n25|2n25]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n26 OCA], [http://pdbe.org/2n26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n26 RCSB], [http://www.ebi.ac.uk/pdbsum/2n26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n26 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n26 OCA], [https://pdbe.org/2n26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n26 RCSB], [https://www.ebi.ac.uk/pdbsum/2n26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n26 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZBT17_HUMAN ZBT17_HUMAN]] Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.<ref>PMID:9312026</ref> <ref>PMID:9308237</ref> <ref>PMID:19164764</ref>
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[https://www.uniprot.org/uniprot/ZBT17_HUMAN ZBT17_HUMAN] Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.<ref>PMID:9312026</ref> <ref>PMID:9308237</ref> <ref>PMID:19164764</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Miz-1 is a BTB/POZ transcription factor that contains 13C2H2 Zinc Finger domains (ZF). Miz-1 transactivates and represses the transcription of a myriad of genes involved in many aspects of the biology of the cell. The detailed molecular interactions through which Miz-1 controls transcription, including its specific DNA binding via its ZF domains, remain to be understood and documented. In our effort to shed light into the structural biology of Miz-1, we have undertaken the determination of the structure of all its ZF and the characterization of their interactions with cognate DNA. The structure of ZF 1 to 10 have already been solved and characterized. Here, we present the structure of the synthetic Miz-1 ZF13 determined by 2D (1)H-(1)H NMR.
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Solution structure of the 13th C2H2 Zinc Finger of Miz-1.,Tremblay C, Bedard M, Bonin MA, Lavigne P Biochem Biophys Res Commun. 2016 Apr 29;473(2):471-5. doi:, 10.1016/j.bbrc.2016.03.034. Epub 2016 Mar 10. PMID:26972249<ref>PMID:26972249</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2n26" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bedard, M]]
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[[Category: Homo sapiens]]
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[[Category: Lavigne, P]]
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[[Category: Large Structures]]
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[[Category: C2h2 zinc finger]]
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[[Category: Bedard M]]
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[[Category: Dna binding protein]]
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[[Category: Lavigne P]]
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[[Category: Miz-1]]
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[[Category: Zbtb17]]
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Current revision

Solution structure of Miz-1 zinc fingers 3 and 4

PDB ID 2n26

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