4xih

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==Crystal structure of the R116A mutant AhpE from Mycobacterium tuberculosis==
==Crystal structure of the R116A mutant AhpE from Mycobacterium tuberculosis==
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<StructureSection load='4xih' size='340' side='right' caption='[[4xih]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='4xih' size='340' side='right'caption='[[4xih]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CCDC5079 Mycobacterium tuberculosis CCDC5079]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XIH FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xxu|1xxu]], [[4x0x|4x0x]], [[1xvw|1xvw]], [[4x1u|4x1u]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xih OCA], [http://pdbe.org/4xih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xih RCSB], [http://www.ebi.ac.uk/pdbsum/4xih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xih ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xih OCA], [https://pdbe.org/4xih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xih RCSB], [https://www.ebi.ac.uk/pdbsum/4xih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xih ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AHPE_MYCTU AHPE_MYCTU] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. May represent an important antioxidant defense against cytotoxic peroxides, especially peroxynitrite, which can be formed by activated macrophages during infection.<ref>PMID:19737009</ref> <ref>PMID:24379404</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dufe, V Tamu]]
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[[Category: Large Structures]]
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[[Category: Messens, J]]
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[[Category: Mycobacterium tuberculosis CCDC5079]]
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[[Category: Molle, I van]]
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[[Category: Messens J]]
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[[Category: Pallo, A]]
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[[Category: Pallo A]]
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[[Category: Oxidoreductase]]
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[[Category: Tamu Dufe V]]
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[[Category: Peroxiredoxin]]
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[[Category: Van Molle I]]

Current revision

Crystal structure of the R116A mutant AhpE from Mycobacterium tuberculosis

PDB ID 4xih

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