4utf

<StructureSection load='4utf' size='340' side='right' caption='[[4utf]], [[Resolution|resolution]] 1.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[4utf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UTF FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IFM:5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE'>IFM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein_endo-alpha-1,2-mannosidase Glycoprotein endo-alpha-1,2-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.130 3.2.1.130] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4utf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4utf OCA], [http://pdbe.org/4utf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4utf RCSB], [http://www.ebi.ac.uk/pdbsum/4utf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4utf ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall alpha-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast alpha-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of alpha-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.

 

== References ==

[[Category: Glycoprotein endo-alpha-1,2-mannosidase]]

[[Category: Abbott, D W]]

[[Category: Atherly, T]]

[[Category: Boraston, A B]]

[[Category: Bracke, D]]

[[Category: Cameron, E A]]

[[Category: Cartmell, A]]

[[Category: Cuskin, F]]

[[Category: Davies, G J]]

[[Category: Gilbert, H J]]

[[Category: Hakki, Z]]

[[Category: Lowe, E C]]

[[Category: Martens, E C]]

[[Category: McLean, R]]

[[Category: Munoz-Munoz, J L]]

[[Category: Pena, M J]]

[[Category: Piens, K]]

[[Category: Pudlo, N A]]

[[Category: Rogowski, A]]

[[Category: Speciale, G]]

[[Category: Suits, M D]]

[[Category: Temple, M J]]

[[Category: Thompson, A J]]

[[Category: Tolbert, T]]

[[Category: Urs, K]]

[[Category: Vervecken, W]]

[[Category: Williams, S J]]

[[Category: Zhu, Y]]

[[Category: Ziemer, C J]]

[[Category: Yeast]]