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| - | [[Image:1n81.jpg|left|200px]] | |
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| - | {{Structure
| + | ==Crystal structure of Pfg27 from Plasmodium falciparum== |
| - | |PDB= 1n81 |SIZE=350|CAPTION= <scene name='initialview01'>1n81</scene>, resolution 2.10Å
| + | <StructureSection load='1n81' size='340' side='right'caption='[[1n81]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND=
| + | <table><tr><td colspan='2'>[[1n81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N81 FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | |GENE= Pfg27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [https://pdbe.org/1n81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB], [https://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n81 ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | == Function == |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n81 OCA], [http://www.ebi.ac.uk/pdbsum/1n81 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n81 RCSB]</span>
| + | [https://www.uniprot.org/uniprot/Q8IEU2_PLAF7 Q8IEU2_PLAF7] |
| - | }}
| + | __TOC__ |
| - | | + | </StructureSection> |
| - | '''Crystal structure of Pfg27 from Plasmodium falciparum'''
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Plasmodium falciparum 3D7]] |
| - | | + | [[Category: Kogkasuriyachai D]] |
| - | ==Overview==
| + | [[Category: Kumar N]] |
| - | Malaria transmission is dependent on the development of sexual forms of Plasmodium falciparum, called gametocytes, in the vertebrate host. Pfg27 is an abundantly expressed sexual stage-specific protein that is essential for gametocytogenesis in P. falciparum. We describe the crystal structure of Pfg27, which reveals a novel fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif. Structurally equivalent helices of each repeat either form a dimer interface or interact with RNA in vitro. One side of the dimer presents an unprecedented juxtaposition of four polyproline (PXXP) motifs. Preliminary binding data indicate that these sites are capable of binding Src homology-3 (SH3) modules. Molecular modeling suggests that the dimer can accommodate two SH3 modules simultaneously, potentially enabling molecular crosstalk between SH3-containing proteins. The structural and initial biochemical evidence suggests that Pfg27 may serve as a platform for RNA and SH3 binding.
| + | [[Category: Sharma A]] |
| - | | + | [[Category: Sharma I]] |
| - | ==About this Structure==
| + | |
| - | 1N81 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N81 OCA].
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| - | | + | |
| - | ==Reference== | + | |
| - | Structure of a gametocyte protein essential for sexual development in Plasmodium falciparum., Sharma A, Sharma I, Kogkasuriyachai D, Kumar N, Nat Struct Biol. 2003 Mar;10(3):197-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12577051 12577051]
| + | |
| - | [[Category: Plasmodium falciparum 3d7]] | + | |
| - | [[Category: Single protein]] | + | |
| - | [[Category: Kogkasuriyachai, D.]] | + | |
| - | [[Category: Kumar, N.]] | + | |
| - | [[Category: Sharma, A.]] | + | |
| - | [[Category: Sharma, I.]] | + | |
| - | [[Category: gametocyte]]
| + | |
| - | [[Category: helical]]
| + | |
| - | [[Category: helix-turn-helix]]
| + | |
| - | [[Category: pxxp]]
| + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:41 2008''
| + | |
