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4gsu

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==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==
==Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains==
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<StructureSection load='4gsu' size='340' side='right' caption='[[4gsu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4gsu' size='340' side='right'caption='[[4gsu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GSU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gsq|4gsq]], [[4gsr|4gsr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DWZ:(2S,3R,4S)-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-2-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-METHYL-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>DWZ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lppS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [https://pdbe.org/4gsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [https://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsu OCA], [http://pdbe.org/4gsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gsu RCSB], [http://www.ebi.ac.uk/pdbsum/4gsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsu ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: An, D R]]
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[[Category: Large Structures]]
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[[Category: Han, B W]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Im, H N]]
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[[Category: An DR]]
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[[Category: Kim, H S]]
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[[Category: Han BW]]
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[[Category: Kim, J]]
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[[Category: Im HN]]
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[[Category: Kim, J Y]]
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[[Category: Kim HS]]
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[[Category: Kim, S J]]
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[[Category: Kim J]]
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[[Category: Lee, J Y]]
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[[Category: Kim JY]]
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[[Category: Min, H K]]
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[[Category: Kim S-J]]
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[[Category: Suh, S W]]
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[[Category: Lee JY]]
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[[Category: Yoon, H J]]
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[[Category: Min HK]]
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[[Category: Yoon, J Y]]
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[[Category: Suh SW]]
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[[Category: D-transpeptidase]]
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[[Category: Yoon HJ]]
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[[Category: Transferase]]
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[[Category: Yoon JY]]

Current revision

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

PDB ID 4gsu

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